Phasing in on the cell cycle

被引:27
作者
Boeynaems, Steven [1 ,2 ,3 ,4 ]
Tompa, Peter [5 ,6 ]
Van den Bosch, Ludo [1 ,2 ,3 ]
机构
[1] KU Leuven Univ Leuven, Dept Neurosci, Expt Neurol, B-3000 Leuven, Belgium
[2] KU Leuven Univ Leuven, Leuven Res Inst Neurosci & Dis LIND, B-3000 Leuven, Belgium
[3] VIB, Lab Neurobiol, Ctr Brain & Dis Res, B-3000 Leuven, Belgium
[4] Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA
[5] VUB, CSB, VIB, Brussels, Belgium
[6] Hungarian Acad Sci, Res Ctr Nat Sci, Inst Enzymol, Budapest, Hungary
基金
欧洲研究理事会;
关键词
Protein phase separation; Oncogenic fusion; Protein aggregation; Cancer; Stress granules; Nucleolus; Centrosome; INTRINSICALLY DISORDERED PROTEINS; NOVO PURINE BIOSYNTHESIS; LOW-COMPLEXITY DOMAINS; RNA-BINDING PROTEINS; C-TERMINAL DOMAIN; STRESS GRANULES; LIQUID DROPLETS; IN-VITRO; NUCLEOCYTOPLASMIC TRANSPORT; HEXANUCLEOTIDE REPEAT;
D O I
10.1186/s13008-018-0034-4
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Just like all matter, proteins can also switch between gas, liquid and solid phases. Protein phase transition has claimed the spotlight in recent years as a novel way of how cells compartmentalize and regulate biochemical reactions. Moreover, this discovery has provided a new framework for the study of membrane-less organelle biogenesis and protein aggregation in neurodegenerative disorders. We now argue that this framework could be useful in the study of cell cycle regulation and cancer. Based on our work on phase transitions of arginine-rich proteins in neurodegeneration, via combining mass spectroscopy with bioinformatics analyses, we found that also numerous proteins involved in the regulation of the cell cycle can undergo protein phase separation. Indeed, several proteins whose function affects the cell cycle or are associated with cancer, have been recently found to phase separate from the test tube to cells. Investigating the role of this process for cell cycle proteins and understanding its molecular underpinnings will provide pivotal insights into the biology of cell cycle progression and cancer.
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页数:8
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