2,4,6-Trihydroxybenzaldehyde, a potential anti-obesity treatment, suppressed adipocyte differentiation in 3T3-L1 cells and fat accumulation induced by high-fat diet in C57BL/6 mice

被引：15

作者：

Kim, Kil-Nam ^{[1
]}

Kang, Min-Cheol ^{[2
]}

Kang, Nalae ^{[2
]}

Kim, Seo-Young ^{[2
]}

Hyun, Chang-Gu ^{[3
]}

Roh, Seong Woon ^{[1
]}

Ko, Eun-Yi ^{[1
,2
]}

Cho, Kichul ^{[1
]}

Jung, Won-Kyo ^{[4
,5
]}

Ahn, Ginnae ^{[6
]}

Jeon, You-Jin ^{[2
]}

Kim, Daekyung ^{[1
]}

机构：

[1] KBSI, Jeju Ctr, Jeju 690140, South Korea

[2] Jeju Natl Univ, Sch Marine Biomed Sci, Jeju 690756, South Korea

[3] Jeju Natl Univ, Fac Chem & Cosmet, Cosmet Sci Ctr, Jeju 690756, South Korea

[4] Pukyong Natl Univ, Dept Biomed Engn, Busan 608737, South Korea

[5] Pukyong Natl Univ, Ctr Marine Integrated Biomed Technol BK21 Plus, Busan 608737, South Korea

[6] Chonnam Natl Univ, Dept Marine Biofood Sci, Yeosu 550749, South Korea

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2015年 / 39卷 / 02期

关键词：

2,4,6-Trihydroxybenzaldehyde (THB); Anti-obesity; 3T3-L1; cells; High fat diet (HFD); C57BL/6; mice; MITOTIC CLONAL EXPANSION; BINDING PROTEIN; OBESITY; EXPRESSION; ACID; RATS; ADIPOGENESIS; GAMMA;

D O I：

10.1016/j.etap.2015.02.007

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

In the present study, 2,4,6-trihydroxybenzaldehyde (THB) was evaluated for inhibitory effects on adipocyte differentiation in 3T3-L1 cells and anti-obesity effects in mice with high-fat diet (HFD)-induced obesity. Lipid accumulation measurement indicated that THB markedly inhibited adipogenesis, and this involved down-regulation of the expression of the adipogenesis-related proteins, CCAAT/enhancer-binding protein alpha (C/EBP alpha), peroxisome proliferator-activated receptor gamma (PPAR-gamma), fatty acid synthase (FAS) and sterol regulatory element-binding protein-1c (SREBP-1c), in 3T3-L1 pre-adipocyte cells. In a mouse model of HFD-induced obesity, oral administration of THB (5 and 25 mg/kg for 13 weeks) reduced the HFD-induced increase in weight gain. THB administration also reduced serum levels of glucose, triglycerides, and total cholesterol. A reduction in the hypertrophy of white adipose tissue was also observed. Furthermore, THB administration inhibited HFD-induced hepatic steatosis. These results provided evidence that administration of THB alleviated HFD-induced obesity in C57BL/6 mice and revealed the potential of THB as a nutraceutical to help prevent or treat obesity and the associated metabolic disorders. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：962 / 968

页数：7