Colorectal Large-Cell Neuroendocrine Carcinoma: Case Report and Literature Review for Potential Novel Therapeutic Options

被引：1

作者：

Chen, Xiaoyi ^{[1
]}

Wang, Xiaoyang ^{[1
]}

Abadi, Maria ^{[2
]}

Kumar, Abhishek ^{[3
]}

机构：

[1] Albert Einstein Coll Med, Jacobi Med Ctr, Dept Med, Bronx, NY 10467 USA

[2] Albert Einstein Coll Med, Jacobi Med Ctr, Dept Pathol, Bronx, NY 10467 USA

[3] Albert Einstein Coll Med, Jacobi Med Ctr, Dept Hematol Oncol, 1400 Pelham Pkwy South,Bldg 1,Room 3N20, Bronx, NY 10461 USA

来源：

CLINICAL COLORECTAL CANCER | 2020年 / 19卷 / 01期

关键词：

Bevacizumab; Chemotherapy; Everolimus; Immunotherapy; Targeted therapy; TUMORS; SURVIVAL; COLON; COMBINATION; EVEROLIMUS; ETOPOSIDE; MUTATIONS; RECTUM; SYSTEM;

D O I：

10.1016/j.clcc.2019.10.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Current standard treatment for large-cell colorectal neuroendocrine carcinoma comprises a platinumbased cytotoxic regimen, which has a poor therapeutic effect. Phase 1/2 clinical trials using targeted therapy with everolimus/bevacizumab or immunotherapy with nivolumab with or without ipilimumab/avelumab/ pembrolizumab as a single or combination regimen with chemotherapy involving colorectal large-cell neuroendocrine carcinoma are ongoing. Published by Elsevier Inc.

引用

页码：61 / 64

页数：4

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