Synthesis and properties of 2-benzylidene-8,9-dihydro-7H-furo[2,3-f][1,3]benzoxazin-3(2H)-one derivatives

被引：7
|
作者：
Popova, Antonina V. [1 ]
Bondarenko, Svitlana P. [2 ]
Frasinyuk, Mykhaylo S. [1 ]
机构：
[1] Natl Acad Sci Ukraine, Inst Bioorgan Chem & Petrochem, 1 Murmanska St, UA-02094 Kiev, Ukraine
[2] Natl Univ Food Technol, 68 Volodymyrska St, UA-01601 Kiev, Ukraine
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2016年 / 52卷 / 08期
关键词：
aurone; furo[2,3-f][1,3]benzoxazin-3(2H)-one; primary amine; aminomethylation; Mannich base; MANNICH-BASES; BIOLOGICAL EVALUATION; COUMARIN DERIVATIVES; ISOFLAVONOIDS; CHEMISTRY; AURONES; DESIGN; POTENT;
D O I：
10.1007/s10593-016-1937-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Aminomethylation of 6-hydroxyaurones with primary amines was used to synthesize 2-benzylidene-8,9-dihydro-7H-furo[2,3-f][1,3]-benzoxazin-3(2H)-one derivatives, while opening of 1,3-oxazine ring in the presence of acid gave secondary amines containing a 6-hydroxyaurone moiety. Acetylation of 2-benzylidene-8,9-dihydro-7H-furo[2,3-f][1,3]benzoxazin-3(2H)-ones was also accompanied by opening of 1,3-oxazine ring.
引用
收藏
页码：592 / 600
页数：9
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