p53, cancer and the immune response

被引：244

作者：

Blagih, Julianne ^{[1
]}

Buck, Michael D. ^{[1
]}

Vousden, Karen H. ^{[1
]}

机构：

[1] Francis Crick Inst, 1 Midland Rd, London NW1 1AT, England

来源：

JOURNAL OF CELL SCIENCE | 2020年 / 133卷 / 05期

基金：

英国惠康基金; 英国医学研究理事会; 加拿大健康研究院;

关键词：

p53; Cancer; Immune response; NF-KAPPA-B; TUMOR-SUPPRESSOR P53; HELICOBACTER-PYLORI INFECTION; T-CELL RESPONSES; MUTANT P53; BREAST-CANCER; WILD-TYPE; OVARIAN-CANCER; STROMAL CELLS; INFLAMMATORY RESPONSE;

D O I：

10.1242/jcs.237453

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The importance of cancer-cell-autonomous functions of the tumour suppressor p53 (encoded by TP53) has been established in many studies, but it is now clear that the p53 status of the cancer cell also has a profound impact on the immune response. Loss or mutation of p53 in cancers can affect the recruitment and activity of myeloid and T cells, allowing immune evasion and promoting cancer progression. p53 can also function in immune cells, resulting in various outcomes that can impede or support tumour development. Understanding the role of p53 in tumour and immune cells will help in the development of therapeutic approaches that can harness the differential p53 status of cancers compared with most normal tissue.

引用

页数：13

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