Vaccines and Broadly Neutralizing Antibodies for HIV-1 Prevention

被引：79

作者：

Stephenson, Kathryn E. ^{[1
,2
]}

Wagh, Kshitij ^{[3
,4
]}

Korber, Bette ^{[3
,4
]}

Barouch, Dan H. ^{[1
,2
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02215 USA

[2] Ragon Inst Massachusetts Gen Hosp MIT & Harvard, Boston, MA 02114 USA

[3] Los Alamos Natl Lab, Theoret Biol & Biophys Grp, Los Alamos, NM 87545 USA

[4] New Mexico Consortium, Los Alamos, NM 87545 USA

来源：

ANNUAL REVIEW OF IMMUNOLOGY, VOL 38 | 2020年 / 38卷

基金：

美国国家卫生研究院;

关键词：

vaccine; broadly neutralizing antibody; HIV-1; viral diversity; prevention; bNAb; HUMAN-IMMUNODEFICIENCY-VIRUS; DEMAND PREEXPOSURE PROPHYLAXIS; CELLULAR IMMUNE-RESPONSES; MUCOSAL SHIV CHALLENGE; T-LYMPHOCYTE RESPONSES; HIGHLY PATHOGENIC SIV; ENVELOPE TRIMER; DOUBLE-BLIND; ANTIRETROVIRAL PROPHYLAXIS; ANTI-HIV-1; ANTIBODIES;

D O I：

10.1146/annurev-immunol-080219-023629

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Development of improved approaches for HIV-1 prevention will likely be required for a durable end to the global AIDS pandemic. Recent advances in preclinical studies and early phase clinical trials offer renewed promise for immunologic strategies for blocking acquisition of HIV-1 infection. Clinical trials are currently underway to evaluate the efficacy of two vaccine candidates and a broadly neutralizing antibody (bNAb) to prevent HIV-1 infection in humans. However, the vast diversity of HIV-1 is a major challenge for both active and passive immunization. Here we review current immunologic strategies forHIV-1 prevention, with a focus on current and next-generation vaccines and bNAbs.

引用

页码：673 / 703

页数：31

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