Is caspase-3 inhibition a valid therapeutic strategy in cerebral ischemia?

被引：55

作者：

Loetscher, H ^{[1
]}

Niederhauser, O ^{[1
]}

Kemp, J ^{[1
]}

Gill, R ^{[1
]}

机构：

[1] F Hoffmann La Roche & Cie AG, Pharma Res Basel, CH-4070 Basel, Switzerland

来源：

DRUG DISCOVERY TODAY | 2001年 / 6卷 / 13期

关键词：

D O I：

10.1016/S1359-6446(01)01826-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Neurodegenerative diseases are characterized by progressive impairment of brain function as a consequence of ongoing neuronal cell death. Apoptotic mechanisms have been implicated in this process and a major involvement of caspase-3, a typical pro-apoptotic executioner protease, has been claimed. In this review, the role of caspase-3 in neuronal cell loss in animal models of stroke is discussed and critically evaluated. In summary, it is concluded that the biochemical evidence favoring caspase-3 as a therapeutic target in cerebral ischemia is not convincing, and the development of selective caspase-3 inhibitors for the treatment of human stroke must be viewed as high risk.

引用

页码：671 / 680

页数：10

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