Cytoprotective role of Solanum nigrum against gentamicin-induced kidney cell (Vero cells) damage in vitro

被引：59

作者：

Kumar, VP

Shashidhara, S

Kumar, MM

Sridhara, BY

机构：

[1] Govt Coll Pharm, Dept Pharmacognosy, Bangalore 560027, Karnataka, India

[2] IAH & VB, Ctr Cell Culture Facil, Bangalore, Karnataka, India

来源：

FITOTERAPIA | 2001年 / 72卷 / 05期

关键词：

Solanum nigrum; cytoprotective activity; Vero cells;

D O I：

10.1016/S0367-326X(01)00266-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The 50% ethanol extract of the whole plant of Solanum nigrum was tested in vitro for its cytoprotection against gentamicin-induced toxicity on Vero cells. Cytotoxicity was significantly inhibited as assessed by the Trypan blue exclusion assay and mitochondrial dehydrogenase activity (MTT) assay. The test extract also exhibited significant hydroxyl radical scavenging potential, thus suggesting its probable mechanism of cytoprotection. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：481 / 486

页数：6

共 17 条

[1] Role of cytochrome P-450 in hydrogen peroxide-induced cytotoxicity to LLC-PK1 cells [J].

Baliga, R ;

Zhang, ZW ;

Shah, SV .

KIDNEY INTERNATIONAL, 1996, 50 (04) :1118-1124

[2]

CARMICHAEL J, 1987, CANCER RES, V47, P943

[3]

HARBORNE JB, 1984, PHYTOCHEMICAL METHOD, P55

[4]

HUMES HD, 1986, KIDNEY, V2, P1491

[5]

HUSSAIN ODA, 1992, DICT INDIAN MED PLAN, P35

[6]

KIRTIKAR KR, 1935, INDIANM ED PLANTS, V3, P457

[7]

KOSEK JC, 1974, LAB INVEST, V30, P48

[8] Effect of Luffa echinata on lipid peroxidation and free radical scavenging activity [J].

Kumar, VP ;

Shashidhara, S ;

Kumar, MM ;

Sridhara, BY .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 2000, 52 (07) :891-894

[9]

MARK AM, 1993, PHARMACOTHERAPY, P701

[10]

*MIN HLTH FAM WELF, 1989, AYURV PHARM IND 1, V2, P59

← 1 2 →