Moxifloxacin:: a comparison with other antimicrobial agents of in-vitro activity against Streptococcus pneumoniae

被引:24
作者
Reinert, RR [1 ]
Schlaeger, JJ [1 ]
Lütticken, R [1 ]
机构
[1] Rhein Westfal TH Aachen Hosp, Inst Med Microbiol, Natl Reference Ctr Streptococci, D-52057 Aachen, Germany
关键词
D O I
10.1093/jac/42.6.803
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Two hundred representative isolates, including 26 strains of Streptococcus pneumoniae with intermediate resistance to penicillin, were selected from a collection obtained from blood cultures of patients with bacteraemic pneumococcal pneumonia. The MICs of moxifloxacin (BAY 12-8039), grepafloxacin, sparfloxacin, levofloxacin, ofloxacin, ciprofloxacin, erythromycin, tetracycline and penicillin G were determined by a standard agar dilution technique. Moxifloxacin had the highest in-vitro activity against S. pneumoniae (MIC90 = 0.25 mg/L; MIC range 0.06-0.25 mg/L). The MIC90 values were one dilution lower than those obtained with sparfloxacin and grepafloxacin, three dilutions lower than those obtained with levofloxacin, and four dilutions lower than those of ofloxacin and ciprofloxacin.
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页码:803 / 806
页数:4
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