Adhesion proteins and the control of cell shape

被引：47

作者：

Carthew, RW ^{[1
]}

机构：

[1] Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Evanston, IL 60208 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2005年 / 15卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.gde.2005.06.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The adherens junction functions to connect epithelial cells and maintain their polarized architecture. The geometry of the adherens junction, and consequently the shape of a cell, appears to reach an energetically favorable state. Cadherins within the adherens junction are necessary for cells to achieve this state. However, the view of an adherens junction as a static structure is at odds with the highly dynamic properties of epithelia during development. Interactions between the actin cytoskeleton and the adherens junction are required for certain cell shape changes. Recent insights into adherens junction remodeling have revealed the importance of polarized localization of myosin and Par3 at the adherens junction.

引用

页码：358 / 363

页数：6

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