Identification of epilepsy-related genes by gene expression profiling in the hippocampus of genetically epileptic rat

被引：9

作者：

Arai, M

Amano, S

Ryo, A

Hada, A

Wakatsuki, T

Shuda, M

Kondoh, N

Yamamoto, M

机构：

[1] Natl Def Med Coll, Dept Biochem 2, Tokorozawa, Saitama 3590042, Japan

[2] Kyoto Univ, Coll Med Technol, Kyoto 6068507, Japan

[3] Harvard Univ, Sch Med, Canc Biol Program, Hematol Oncol Div, Boston, MA 02215 USA

[4] SciMedia Ltd, Tsukuba, Ibaraki 3002635, Japan

[5] Tokyo Metropolitan Inst Med Sci, Dept Microbiol & Cell Biol, Bunkyo Ku, Tokyo 1138613, Japan

来源：

MOLECULAR BRAIN RESEARCH | 2003年 / 118卷 / 1-2期

关键词：

Ihara epileptic rat; microdysgenesis; hippocampus; epileptogenesis; temporal lobe epilepsy; serial analysis of gene expression;

D O I：

10.1016/S0169-328X(03)00329-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ihara epileptic rat (IER) is an animal model of temporal lobe epilepsy (TLE) with genetically programmed microdysgenesis in the hippocampal formation. The neuronal microdysgenesis is thought to be a cause for recurrent spontaneous seizures. To identify differentially expressed genes in the hippocampus of IER in comparison to control Wistar rat, we performed serial analysis of gene expression (SAGE). As many as 21 differentially expressed genes were identified. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：147 / 151

页数：5

共 25 条

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