TF-Marker: a comprehensive manually curated database for transcription factors and related markers in specific cell and tissue types in human

被引：24

作者：

Xu, Mingcong ^{[1
,2
]}

Bai, Xuefeng ^{[1
,3
,4
]}

Ai, Bo ^{[1
]}

Zhang, Guorui ^{[1
]}

Song, Chao ^{[1
]}

Zhao, Jun ^{[1
]}

Wang, Yuezhu ^{[1
]}

Wei, Ling ^{[1
]}

Qian, Fengcui ^{[1
]}

Li, Yanyu ^{[1
]}

Zhou, Xinyuan ^{[1
]}

Zhou, Liwei ^{[1
]}

Yang, Yongsan ^{[1
]}

Chen, Jiaxin ^{[1
]}

Liu, Jiaqi ^{[2
,5
,6
,7
]}

Shang, Desi ^{[2
,5
,6
,7
]}

Wang, Xuan ^{[1
]}

Zhao, Yu ^{[2
,5
,6
,7
]}

Huang, Xuemei ^{[2
,5
,6
,7
]}

Zheng, Yan ^{[3
,4
]}

Zhang, Jian ^{[1
]}

Wang, Qiuyu ^{[1
,2
,5
,6
,7
]}

Li, Chunquan ^{[1
,2
,5
,6
,7
,8
,9
]}

机构：

[1] Harbin Med Univ, Sch Med Informat, Daqing Campus, Daqing 163319, Peoples R China

[2] Univ South China, Hengyang Med Sch, Inst Cardiovasc Dis, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China

[3] Fudan Univ, Human Phenome Inst, State Key Lab Genet Engn, Shanghai 200438, Peoples R China

[4] Fudan Univ, Sch Life Sci, Shanghai 200438, Peoples R China

[5] Univ South China, Sch Comp, Hengyang 421001, Hunan, Peoples R China

[6] Univ South China, Hengyang Med Sch, Cardiovasc Lab Big Data & Imaging Artificial Inte, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China

[7] Univ South China, Hunan Prov Base Sci & Technol Innovat Cooperat, Hengyang 421001, Hunan, Peoples R China

[8] Capital Med Univ, Beijing Friendship Hosp, Gen Surg Dept, Beijing 100050, Peoples R China

[9] Guilin Med Univ, Guangxi Key Lab Diabet Syst Med, Guilin 541199, Guangxi, Peoples R China

来源：

NUCLEIC ACIDS RESEARCH | 2022年 / 50卷 / D1期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

REGULATORY CIRCUITRY; EXPRESSION; SOX2; ENHANCERS; PROTEIN; CANCER; OCT4;

D O I：

10.1093/nar/gkab1114

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transcription factors (TFs) play key roles in biological processes and are usually used as cell markers. The emerging importance of TFs and related markers in identifying specific cell types in human diseases increases the need for a comprehensive collection of human TFs and related markers sets. Here, we developed the TF-Marker database (TF-Marker, http://bio.liclab.net/TF-Marker/), aiming to provide cell/tissue-specific TFs and related markers for human. By manually curating thousands of published literature, 5905 entries including information about TFs and related markers were classified into five types according to their functions: (i) TF: TFs which regulate expression of the markers; (ii) T Marker: markers which are regulated by the TF; (iii) I Marker: markers which influence the activity of TFs; (iv) TFMarker: TFs which play roles as markers and (v) TF Pmarker: TFs which play roles as potential markers. The 5905 entries of TF-Marker include 1316 TFs, 1092 T Markers, 473 I Markers, 1600 TFMarkers and 1424 TF Pmarkers, involving 383 cell types and 95 tissue types in human. TF-Marker further provides a user-friendly interface to browse, query and visualize the detailed information about TFs and related markers. We believe TF-Marker will become a valuable resource to understand the regulation patterns of different tissues and cells.

引用

页码：D402 / D412

页数：11

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