N-6 SUBSTITUTED DEOXYGENATED DERIVATIVES OF L-LIKE 5′-NORARISTEROMYCIN

被引：0

作者：

Yu, Henry ^{[1
]}

Serbessa, Tesfaye ^{[1
]}

机构：

[1] Elizabeth City State Univ, Dept Chem Geol & Phys, Elizabeth City, NC 27909 USA

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA | 2010年 / 24卷 / 03期

关键词：

L-like; Carbocyclic nucleosides; HBV;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Several N-6 substituted derivatives (4-11) of (+)-4'-deoxy-5'-noraristeromycin (2) and its unsaturated counterpart (3) have been prepared. The derivatives are designed to systematically vary the hydrophobic/hydrophilic balance of the lead compounds. These compounds were evaluated against a large number of viruses but no significant antiviral activity was observed. Also, no cytotoxicity to host cells was found.

引用

页码：439 / 446

页数：8

共 17 条

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