Copper-Catalyzed Oxidative Trifluoromethylation of Terminal Alkenes Using Nucleophilic CF3SiMe3: Efficient C(sp3)-CF3 Bond Formation

被引：159

作者：

Chu, Lingling ^{[2
]}

Qing, Feng-Ling ^{[1
]}

机构：

[1] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 08期

基金：

中国国家自然科学基金;

关键词：

C-H; MEDIATED TRIFLUOROMETHYLATION; REDUCTIVE ELIMINATION; MEDICINAL CHEMISTRY; BORONIC ACIDS; ARYL IODIDES; ARENES; PERFLUOROALKYLATION; FLUORINATION; REAGENT;

D O I：

10.1021/ol300639a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient C(sp(3))-CF3 bond-forming reaction via Cu-catalyzed oxidative trifluoromethylation of terminal alkenes has been developed, which proceeds under mild conditions using readily available, less expensive CF3SiMe3 as the source of the CF3 group. This method allows access to a variety of trifluoromethylated allylic compounds.

引用

页码：2106 / 2109

页数：4

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