Efficient synthesis of methyl carbamate via Hofmann rearrangement in the presence of TsNBr2

被引：29

作者：

Borah, Arun Jyoti ^{[1
]}

Phukan, Prodeep ^{[1
]}

机构：

[1] Guwahati Univ, Dept Chem, Gauhati 781014, Assam, India

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 24期

关键词：

TsNBr2; Hofmann rearrangement; Amides; Carbamate; STEREOSELECTIVE-SYNTHESIS; AMIDES; MEDIA;

D O I：

10.1016/j.tetlet.2012.04.011

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method has been developed for the synthesis of carbamates from the corresponding amides via the Hofmann rearrangement using N,N-dibromo-p-toluenesulfonamide (TsNBr2) in the presence of DBU in methanol. The reaction goes into completion in 10-20 min at 65 degrees C to produce the corresponding carbamate in excellent yield. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：3035 / 3037

页数：3

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