Recent progress in tumor photodynamic immunotherapy

被引：96

作者：

Shen, Lijun ^{[1
]}

Zhou, Tianjiao ^{[1
]}

Fan, Yatong ^{[1
]}

Chang, Xin ^{[1
]}

Wang, Yi ^{[1
]}

Sun, Jianguo ^{[5
]}

Xing, Lei ^{[1
,2
,3
,4
]}

Jiang, Hulin ^{[1
,2
,3
,4
]}

机构：

[1] China Pharmaceut Univ, Dept Pharmaceut, State Key Lab Nat Med, Nanjing 210009, Peoples R China

[2] China Pharmaceut Univ, Jiangsu Key Lab Druggabil Biopharmaceut, Nanjing 210009, Peoples R China

[3] China Pharmaceut Univ, Jiangsu Key Lab Drug Screening, Nanjing 210009, Peoples R China

[4] China Pharmaceut Univ, Jiangsu Key Lab Drug Discovery Metab Dis, Nanjing 210009, Peoples R China

[5] China Pharmaceut Univ, State Key Lab Nat Med, Key Lab Drug Metab & Pharmacokinet, Nanjing 210009, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2020年 / 31卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Cancer therapy; Photodynamic therapy; Immunotherapy; Reactive oxygen species; Singlet oxygen; CANCER-IMMUNOTHERAPY; CHECKPOINT BLOCKADE; ANTITUMOR IMMUNITY; DENDRITIC CELLS; THERAPY; COMBINATION; RESISTANCE; PHOTOSENSITIZERS; NANOPARTICLES; INFLAMMATION;

D O I：

10.1016/j.cclet.2020.02.007

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Photodynamic therapy (PDT) is a promising alternative approach for effective cancer treatment, which can directly destroy local tumor cells due to the generation of cytotoxic singlet oxygen and reactive oxygen species (ROS) in the tumor cells. Intriguingly, PDT-mediated cell death is also associated with anti-tumor immune response. However, immunosuppression of tumor microenvironment is able to limit the immune response induced by PDT, it is therefore necessary to combine with immunocheckpoint inhibitor and immunoadjuvant for synergistic treatment of tumors. Herein, the recent advances of PDT, immunotherapy, and photodynamic immunotherapy are reviewed (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

引用

页码：1709 / 1716

页数：8

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