[18F]-fluorodeoxyglucose positron emission tomography of the cat brain: A feasibility study to investigate osteoarthritis-associated pain

被引：19

作者：

Guillot, Martin ^{[1
,2
]}

Chartrand, Gabriel ^{[3
]}

Chav, Ramnada ^{[3
]}

Rousseau, Jacques ^{[4
,5
]}

Beaudoin, Jean-Francois ^{[4
]}

Martel-Pelletier, Johanne ^{[2
]}

Pelletier, Jean-Pierre ^{[2
]}

Lecomte, Roger ^{[4
,5
]}

de Guise, Jacques A. ^{[3
]}

Troncy, Eric ^{[1
,2
]}

机构：

[1] Univ Montreal, Fac Med Vet, GREPAQ, St Hyacinthe, PQ J2S 7C6, Canada

[2] Univ Montreal, Fac Med, Dept Med, Osteoarthrit Res Unit,Univ Montreal Hosp Res Ctr, Montreal, PQ H3C 3J7, Canada

[3] Univ Quebec, Ecole Technol Super, Univ Montreal Hosp Res Ctr CRCHUM, Lab Rech Imagerie & Orthopedie LIO, Montreal, PQ H3C 3P8, Canada

[4] CHU Sherbrooke, Etienne Le Bel Clin Res Ctr, CIMS, Sherbrooke, PQ J1H 5N4, Canada

[5] Univ Sherbrooke, Fac Med & Hlth Sci, Dept Nucl Med & Radiobiol, Sherbrooke, PQ J1K 2R1, Canada

来源：

VETERINARY JOURNAL | 2015年 / 204卷 / 03期

基金：

加拿大创新基金会; 加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

Brain imaging; Positron emission tomography; Central sensitization; Chronic pain; Cat; Osteoarthritis; CENTRAL SENSITIZATION; ANIMAL-MODELS; MECHANISMS; ANESTHESIA; DIAGNOSIS; RECEPTOR;

D O I：

10.1016/j.tvjl.2015.03.023

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The objective of this pilot study was to investigate central nervous system (CNS) changes related to osteoarthritis (OA)-associated chronic pain in cats using [F-18]-fluorodeoxyglucose ((18)FDG) positron emission tomography (PET) imaging. The brains of five normal, healthy (non-OA) cats and seven cats with pain associated with naturally occurring OA were imaged using (18)FDG-PET during a standardized mild anesthesia protocol. The PET images were co-registered over a magnetic resonance image of a cat brain segmented into several regions of interest. Brain metabolism was assessed in these regions using standardized uptake values. The brain metabolism in the secondary somatosensory cortex, thalamus and periaqueductal gray matter was increased significantly (P <= 0.005) in OA cats compared with non-OA cats. This study indicates that (18)FDG-PET brain imaging in cats is feasible to investigate CNS changes related to chronic pain. The results also suggest that OA is associated with sustained nociceptive inputs and increased activity of the descending modulatory pathways. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：299 / 303

页数：5

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