Synthesis, Crystal Structures, Hydrogen Bonds and Antibacterial Activity of New Quinoline Derivatives

Two new quinolines derivatives where crystallized from the acetylation reaction in low temperature ; between Baylis-Hillman products which had themselves been prepared from the Meth Cohn method and catalyzed by 1,4-diazabicyclo (Fatiha et al. in J Chem Crystallogr 42:989-996, 2012) octane and silicon dioxide or in pyridine and chloroform. Chemical structures have been established by spectral techniques of FTIR, 1H NMR and X-ray single crystal in low temperature. The crystal structure of (1a) crystallizes in triclinic space group P-1, a = 7.9145(12) angstrom, b = 9.1412(11) angstrom, c = 10.7286(16) angstrom, alpha = 94.760(11)degrees, beta = 105.988(13)degrees , gamma = 101.818(11)degrees, while (2a) crystallizes in orthorhombic non- centrosymmetric space group Pna21, a = 7.7237(12) angstrom, b = 20.2539(28) angstrom, c = 8.7164(12) angstrom, and its cohesion was found to be assured by O-H center dot center dot center dot O and C-H center dot center dot center dot O hydrogen bonds. Antimicrobial activity (in vitro) was evaluated by Gram-positive and Gram-negative bacteria. The compounds have shown good biological activity with Gram-positive bacteria (Staphylococcus aurous and Staphylococcus coagulase-negative). Graphical Abstract Two new Quinoline derivatives have been prepared with good products yields; these products constitute original compounds, of great interest biological activity.