Transmission of CMV, HTLV-1, and HIV through breastmilk

被引：44

作者：

Prendergast, Andrew J. ^{[1
,2
]}

Goga, Ameena E. ^{[3
,4
]}

Waitt, Catriona ^{[5
,6
]}

Gessain, Antoine ^{[7
]}

Taylor, Graham P. ^{[8
]}

Rollins, Nigel ^{[9
]}

Abrams, Elaine J. ^{[10
,11
]}

Lyall, E. Hermione ^{[12
]}

Van de Perre, Philippe ^{[13
]}

机构：

[1] Queen Mary Univ London, Blizard Inst, London, England

[2] Zvitambo Inst Maternal & Child Hlth Res, Harare, Zimbabwe

[3] South African Med Res Council, Cape Town, South Africa

[4] Univ Pretoria, Dept Paediat, Hatfield, South Africa

[5] Univ Liverpool, Dept Mol & Clin Pharmacol, Liverpool, Merseyside, England

[6] Makerere Univ, Infect Dis Inst, Coll Hlth Sci, Kampala, Uganda

[7] Inst Pasteur, EPVO Unit, Paris, France

[8] Imperial Coll London, Sect Virol, London, England

[9] WHO, Dept Maternal Newborn Child & Adolescent Hlth, Geneva, Switzerland

[10] Columbia Univ, ICAP Columbia, Mailman Sch Publ Hlth, New York, NY USA

[11] Columbia Univ, Vagelos Coll Phys & Surg, New York, NY USA

[12] Imperial Coll Healthcare NHS Trust, Dept Paediat, London, England

[13] Univ Montpellier, CHU Montpellier, Pathogenesis & Control Chron Infect, INSERM,Etab Francais Sang, Montpellier, France

来源：

LANCET CHILD & ADOLESCENT HEALTH | 2019年 / 3卷 / 04期

关键词：

TO-CHILD TRANSMISSION; ACTIVE ANTIRETROVIRAL THERAPY; POSTNATAL CYTOMEGALOVIRUS-INFECTION; SUB-SAHARAN AFRICA; PRETERM INFANTS; CELL-LEUKEMIA/LYMPHOMA; DRUG-RESISTANCE; VIRUS; MOTHER; WOMEN;

D O I：

10.1016/S2352-4642(19)30024-0

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Breastfeeding is a crucial child survival intervention. However, the potential for transmission of viral infections from mother to child presents the dilemma of how best to interpret the benefits and risks of breastfeeding in different settings. In this Review, we compare the transmission dynamics, risk factors, and outcomes of infection with three chronic viruses transmitted through breastmilk: cytomegalovirus, human T-cell lymphotropic virus type 1, and HIV. We provide an overview of intervention approaches and discuss scientific, policy, and programming gaps in the understanding of these major global infections.

引用

页码：264 / 273

页数：10

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