MICROWAVE-ASSISTED SYNTHESIS OF IMIDAZO[1,2-a] PYRIDINE DERIVATIVES AND THEIR ANTI-INFLAMMATORY ACTIVITY

被引：1

作者：

Budumuru, Pushpalatha ^{[1
]}

Golagani, Srinivasarao ^{[1
]}

Pushpanjali, B. ^{[2
]}

机构：

[1] GITAM Deemed Be Univ, Dept Chem, Inst Sci, Visakhapatnam 530045, Andhra Pradesh, India

[2] Dr BRKR Govt Ayurved Med Coll, Hyderabad 500018, Telangana, India

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2019年 / 10卷 / 03期

关键词：

Imidazo[1,2-a] pyridine; biological activity; Microwave irradiation; Antiinflammatory activity; INFLAMMATION; INHIBITION; X22; CHEMISTRY; PREVENTS; INJURY;

D O I：

10.13040/IJPSR.0975-8232.10(3).1172-79

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A series of novel Imidazo[1,2-a] pyridine derivatives were synthesized in satisfactory yield by microwave assisted synthetic method. The structures of the newly synthesized compounds are characterized by H-1-nuclear magnetic resonance (NMR), Fourier transformed infrared (FTIR), mass spectral analysis (LC-MS) and screened for their in-vitro anti-inflammatory activity. Among the synthesized compounds N-(3,5-bis(trifluoromethyl)benzyl)-4-((2-(6-methyl-2-(p-tolyl) imidazo [1,2-a] pyridine-3-yl) acetamido)methyl) benzamide and N- (4-methoxybenzyl)-4- ((2-(6-methyl-2-(p-tolyl) imidazo [1,2-a] pyridin-3-yl) acetamido) methyl) benzamide are possessing high anti-inflammatory activity against standard drug Aspirin. A majority of the tested compounds had shown good consequence to moderate anti-inflammatory activity.

引用

页码：1172 / 1179

页数：8

共 25 条

[1] Identification of Novel Imidazo[1,2-a]pyridine Inhibitors Targeting M. tuberculosis QcrB [J].

Abrahams, Katherine A. ;

Cox, Jonathan A. G. ;

Spivey, Vickey L. ;

Loman, Nicholas J. ;

Pallen, Mark J. ;

Constantinidou, Chrystala ;

Fernandez, Raquel ;

Alemparte, Carlos ;

Remuinan, Modesto J. ;

Barros, David ;

Ballell, Lluis ;

Besra, Gurdyal S. .

PLOS ONE, 2012, 7 (12)

[2] DERIVATIVES OF IMIDAZOLE .I. SYNTHESIS AND REACTIONS OF IMIDAZO[1,2-A]PYRIDIENES WITH ANALGESIC ANTIINFLAMMATORY ANTIPYRETIC AND ANTICONVULSANT ACTIVITY [J].

ALMIRANTE, L ;

POLO, L ;

MUGNAINI, A ;

PROVINCIALI, E ;

RUGARLI, P ;

BIANCOTTI, A ;

GAMBA, A ;

MURMANN, W .

JOURNAL OF MEDICINAL CHEMISTRY, 1965, 8 (03) :305-+

[3] Synthesis of imidazo[1,2-a]pyridines: a decade update [J].

Bagdi, Avik Kumar ;

Santra, Sougata ;

Monir, Kamarul ;

Hajra, Alakananda .

CHEMICAL COMMUNICATIONS, 2015, 51 (09) :1555-1575

[4]

Bailey-shaw YA., 2017, INT J PHARM SCI REV, V47, P145

[5] A novel imidazopyridine derivative, X22, prevents the retinal ischemia-reperfusion injury via inhibition of MAPKs [J].

Bian, Yang ;

Ren, Luqing ;

Wang, Lei ;

Xu, Shanmei ;

Tao, Jianjian ;

Zhang, Xiuhua ;

Huang, Yi ;

Qian, Yuanyuan ;

Zhang, Xin ;

Song, Zongming ;

Wu, Wencan ;

Wang, Yi ;

Liang, Guang .

EXPERIMENTAL EYE RESEARCH, 2015, 135 :26-36

[6]

Budumuru P, 2018, ASIAN J PHARM CLIN R, V11, P1

[7] Anti-inflammatory Agents: Present and Future [J].

Dinarello, Charles A. .

CELL, 2010, 140 (06) :935-950

[8]

Gaba M, 2011, INDIAN J PHARM EDUC, V45, P175

[9] THE USE OF MICROWAVE-OVENS FOR RAPID ORGANIC-SYNTHESIS [J].

GEDYE, R ;

SMITH, F ;

WESTAWAY, K ;

ALI, H ;

BALDISERA, L ;

LABERGE, L ;

ROUSELL, J .

TETRAHEDRON LETTERS, 1986, 27 (03) :279-282

[10] Imidazo[1,2-a]pyridines: Promising Drug Candidate for Antitumor Therapy [J].

Goel, Richa ;

Luxami, Vijay ;

Paul, Kamaldeep .

CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2016, 16 (30) :3590-3616

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