Non-Hodgkin lymphoma of the prostate

Lymphoma presenting in the prostate is rare. We report 10 cases of primary non-Hodgkin lymphoma of the prostate from the Nebraska Lymphoma Study Group. The median age of the patients at time of diagnosis was 68.5 years, with presenting symptoms of urinary obstruction and/or dysuria. Six different types of B-cell lymphoma were identified, including four cases of diffuse large B-cell lymphoma, three cases of extranodal marginal zone lymphoma, and one case each of follicular, mantle cell, and small lymphocytic lymphoma. At the time of presentation only one case had an elevated serum lactate dehydrogenase (LDH) level, and two cases were stage 1, one was stage 2, and seven were stage 4. Three patients expired secondary to prostatic lymphoma, four patients expired due to other causes, and three are still alive with no relapse. The prognosis was poor for patients with systemic symptoms at the time of diagnosis, but survival free from relapse lymphoma was possible. When compared to prior reviews, a higher proportion of patients were treated with chemotherapy, which likely contributed to improved survival.