Selenium: An Antioxidant with a Critical Role in Anti-Aging

被引：147

作者：

Bjorklund, Geir ^{[1
]}

Shanaida, Mariia ^{[2
]}

Lysiuk, Roman ^{[3
,4
]}

Antonyak, Halyna ^{[5
]}

Klishch, Ivan ^{[2
]}

Shanaida, Volodymyr ^{[6
]}

Peana, Massimiliano ^{[7
]}

机构：

[1] Council Nutr & Environm Med CONEM, Toften 24, N-8610 Mo I Rana, Norway

[2] I Horbachevsky Ternopil Natl Med Univ, UA-46001 Ternopol, Ukraine

[3] Danylo Halytsky Lviv Natl Med Univ, Dept Pharmacognosy & Bot, UA-79010 Lvov, Ukraine

[4] Danylo Halytsky Lviv Natl Med Univ, CONEM Ukraine Life Sci Res Grp, UA-79010 Lvov, Ukraine

[5] Ivan Franko Natl Univ Lviv, Dept Ecol, UA-79005 Lvov, Ukraine

[6] Ternopil Ivan Puluj Natl Tech Univ, Design Machine Tools Instruments & Machines Dept, UA-46001 Ternopol, Ukraine

[7] Univ Sassari, Dept Chem Phys Math & Nat Sci, I-07100 Sassari, Italy

来源：

MOLECULES | 2022年 / 27卷 / 19期

关键词：

selenium; health benefit; human aging; antioxidant effect; immunoprotection; chemoprevention; LOW SERUM SELENIUM; T-CELL; ORGANO-SELENIUM; ELDERLY-PEOPLE; NANO-SELENIUM; SELENOPROTEINS; CANCER; SUPPLEMENTATION; NANOPARTICLES; METABOLISM;

D O I：

10.3390/molecules27196613

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aging is characterized by an imbalance between damage inflicted by reactive oxygen species (ROS) and the antioxidative defenses of the organism. As a significant nutritional factor, the trace element selenium (Se) may remodel gradual and spontaneous physiological changes caused by oxidative stress, potentially leading to disease prevention and healthy aging. Se is involved in improving antioxidant defense, immune functions, and metabolic homeostasis. An inadequate Se status may reduce human life expectancy by accelerating the aging process or increasing vulnerability to various disorders, including immunity dysfunction, and cancer risk. This review highlights the available studies on the effective role of Se in aging mechanisms and shows the potential clinical implications related to its consumption. The main sources of organic Se and the advantages of its nanoformulations were also discussed.

引用

页数：16

共 149 条

[41] Metals in plasma of nonagenarians and centenarians living in a key area of longevity [J].

Forte, G. ;

Deiana, M. ;

Pasella, S. ;

Baralla, A. ;

Occhineri, P. ;

Mura, I. ;

Madeddu, R. ;

Muresu, E. ;

Sotgia, S. ;

Zinellu, A. ;

Carru, C. ;

Bocca, B. ;

Deiana, L. .

EXPERIMENTAL GERONTOLOGY, 2014, 60 :197-206

[42] LONGEVITY AND SELENIUM DEFICIENCY - EVIDENCE FROM THE PEOPLES-REPUBLIC-OF-CHINA [J].

FOSTER, HD ;

ZHANG, LP .

SCIENCE OF THE TOTAL ENVIRONMENT, 1995, 170 (1-2) :133-139

[43]

Gasmi A., 2022, MOLECULES, V27, P6280

[44] Quercetin in the Prevention and Treatment of Coronavirus Infections: A Focus on SARS-CoV-2 [J].

Gasmi, Amin ;

Mujawdiya, Pavan Kumar ;

Lysiuk, Roman ;

Shanaida, Mariia ;

Peana, Massimiliano ;

Benahmed, Asma Gasmi ;

Beley, Nataliya ;

Kovalska, Nadiia ;

Bjorklund, Geir .

PHARMACEUTICALS, 2022, 15 (09)

[45] Biomarkers of Senescence during Aging as Possible Warnings to Use Preventive Measures [J].

Gasmi, Amin ;

Chirumbolo, Salvatore ;

Peana, Massimiliano ;

Mujawdiya, Pavan Kumar ;

Dadar, Maryam ;

Menzel, Alain ;

Bjorklund, Geir .

CURRENT MEDICINAL CHEMISTRY, 2021, 28 (08) :1471-1488

[46] Naked Selenium Nanoparticles for Antibacterial and Anticancer Treatments [J].

Geoffrion, Luke D. ;

Hesabizadeh, Tina ;

Medina-Cruz, David ;

Kusper, Matthew ;

Taylor, Patrick ;

Vernet-Crua, Ada ;

Chen, Junjiang ;

Ajo, Alessandro ;

Webster, Thomas J. ;

Guisbiers, Gregory .

ACS OMEGA, 2020, 5 (06) :2660-2669

[47] Detection of over 100 selenium metabolites in selenized yeast by liquid chromatography electrospray time-of-flight mass spectrometry [J].

Gilbert-Lopez, Bienvenida ;

Dernovics, Mihaly ;

Moreno-Gonzalez, David ;

Molina-Diaz, Antonio ;

Garcia-Reyes, Juan F. .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2017, 1060 :84-90

[48] Expression of ER-resident selenoproteins and activation of cancer cells apoptosis mechanisms under ER-stress conditions caused by methylseleninic acid [J].

Goltyaev, M. V. ;

Mal'tseva, V. N. ;

Varlamova, E. G. .

GENE, 2020, 755

[49]

Gons'kyi Ia I, 1991, Ukr Biokhim Zh (1978), V63, P112

[50] Life-quality indicators in elderly people are influenced by selenium status [J].

Gonzalez, Sonia ;

Huerta, Jose M. ;

Fernandez, Serafina ;

Patterson, Angeles M. ;

Lasheras, Cristina .

AGING CLINICAL AND EXPERIMENTAL RESEARCH, 2007, 19 (01) :10-15

← 1 2 3 4 5 6 7 8 9 10 →