Differentiation of Sporadic Versus Tuberous Sclerosis Complex-Associated Angiomyolipoma

被引：18
作者：
Rabenou, Rahmin A. [1 ]
Charles, Hearns W. [2 ]
机构：
[1] NYU, Sch Med, Div Nephrol, New York, NY 10016 USA
[2] NYU, Langone Med Ctr, Dept Radiol, Div Vasc & Intervent Radiol, New York, NY 10016 USA
来源：
AMERICAN JOURNAL OF ROENTGENOLOGY | 2015年 / 205卷 / 02期
关键词：
CT; hereditary; mammalian target of rapamycin; MRI; mTOR; neoplastic syndromes; renal angiomyolipoma; tuberous sclerosis complex; RENAL-CELL CARCINOMA; CONTRAST-ENHANCED ULTRASOUND; PULMONARY LYMPHANGIOLEIOMYOMATOSIS; RADIOFREQUENCY ABLATION; MUTATIONAL ANALYSIS; TSC1-TSC2; COMPLEX; PHASE-3; TRIAL; MINIMAL FAT; KIDNEY; GENE;
D O I：
10.2214/AJR.14.14255
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
OBJECTIVE. We review the imaging of renal angiomyolipomas, including differentiation of tuberous sclerosis complex (TSC)-associated and sporadic renal angiomyolipomas and other solid renal tumors. We also focus on radiologic interventions and molecular targeting of the TSC genetic pathway. CONCLUSION. Imaging plays a central role in the diagnosis and management of renal angiomyolipomas. It provides essential information to make the best therapeutic decisions about the interventional and pharmacologic options to help prevent bleeding and preserve functional parenchyma.
引用
收藏
页码：292 / 301
页数：10
相关论文
共 90 条
[41]   Lymphangioleiomyomatiosis [J].
Johnson, SR .
EUROPEAN RESPIRATORY JOURNAL, 2006, 27 (05) :1056-1065
[42]   Activation of the mTOR pathway in sporadic angiomyolipomas and other perivascular epithelioid cell neoplasms [J].
Kenerson, Heidi ;
Fope, Andrew L. ;
Takayama, Thomas K. ;
Yeung, Raymond S. .
HUMAN PATHOLOGY, 2007, 38 (09) :1361-1371
[43]   OUTCOME ANALYSIS OF 42 CASES OF RENAL ANGIOMYOLIPOMA [J].
KENNELLY, MJ ;
GROSSMAN, HB ;
CHO, KJ .
JOURNAL OF UROLOGY, 1994, 152 (06) :1988-1991
[44]   Management of renal angiomyolipoma: Analysis of 15 cases [J].
Kessler, OJ ;
Gillon, G ;
Neuman, M ;
Engelstein, D ;
Winkler, H ;
Baniel, J .
EUROPEAN UROLOGY, 1998, 33 (06) :572-575
[45]   Renal angiomyolipoma with minimal fat: Differentiation trom other neoplasms at double-echo chemical shift FLASH MR imaging [J].
Kim, JK ;
Kim, SH ;
Jang, YJI ;
Ahn, H ;
Kim, CS ;
Park, H ;
Lee, JW ;
Kim, S ;
Cho, KS .
RADIOLOGY, 2006, 239 (01) :174-180
[46]   The effect of everolimus on renal angiomyolipoma in patients with tuberous sclerosis complex being treated for subependymal giant cell astrocytoma: subgroup results from the randomized, placebo-controlled, Phase 3 trial EXIST-1 [J].
Kingswood, J. Chris ;
Jozwiak, Sergiusz ;
Belousova, Elena D. ;
Frost, Michael D. ;
Kuperman, Rachel A. ;
Bebin, E. Martina ;
Korf, Bruce R. ;
Flamini, J. Robert ;
Kohrman, Michael H. ;
Sparagana, Steven P. ;
Wu, Joyce Y. ;
Brechenmacher, Thomas ;
Stein, Karen ;
Berkowitz, Noah ;
Bissler, John J. ;
Franz, David N. .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2014, 29 (06) :1203-1210
[47]   Trends of Presentation and Clinical Outcome of Treated Renal Angiomyolipoma [J].
Koo, Kyo Chul ;
Kim, Won Tae ;
Ham, Won Sik ;
Lee, Jin Sun ;
Ju, Hee Jeong ;
Choi, Young Deuk .
YONSEI MEDICAL JOURNAL, 2010, 51 (05) :728-734
[48]   Sirolimus and tuberous sclerosis-associated renal angiomyolipomas [J].
Krischock, L. ;
Beach, R. ;
Taylor, J. .
ARCHIVES OF DISEASE IN CHILDHOOD, 2010, 95 (05) :391-392
[49]   Encapsulated ultrasound microbubbles: Therapeutic application in drug/gene delivery [J].
Liu, Yiyao ;
Miyoshi, Hirokazu ;
Nakamura, Michihiro .
JOURNAL OF CONTROLLED RELEASE, 2006, 114 (01) :89-99
[50]   MINIMAL FAT RENAL ANGIOMYOLIPOMA: THE INITIAL STUDY WITH CONTRAST-ENHANCED ULTRASONOGRAPHY [J].
Lu, Qing ;
Wang, Wenping ;
Huang, Beijian ;
Li, Chaolun ;
Li, Cong .
ULTRASOUND IN MEDICINE AND BIOLOGY, 2012, 38 (11) :1896-1901
123456789