Differentiation of Sporadic Versus Tuberous Sclerosis Complex-Associated Angiomyolipoma

被引：18
作者：
Rabenou, Rahmin A. [1 ]
Charles, Hearns W. [2 ]
机构：
[1] NYU, Sch Med, Div Nephrol, New York, NY 10016 USA
[2] NYU, Langone Med Ctr, Dept Radiol, Div Vasc & Intervent Radiol, New York, NY 10016 USA
来源：
AMERICAN JOURNAL OF ROENTGENOLOGY | 2015年 / 205卷 / 02期
关键词：
CT; hereditary; mammalian target of rapamycin; MRI; mTOR; neoplastic syndromes; renal angiomyolipoma; tuberous sclerosis complex; RENAL-CELL CARCINOMA; CONTRAST-ENHANCED ULTRASOUND; PULMONARY LYMPHANGIOLEIOMYOMATOSIS; RADIOFREQUENCY ABLATION; MUTATIONAL ANALYSIS; TSC1-TSC2; COMPLEX; PHASE-3; TRIAL; MINIMAL FAT; KIDNEY; GENE;
D O I：
10.2214/AJR.14.14255
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
OBJECTIVE. We review the imaging of renal angiomyolipomas, including differentiation of tuberous sclerosis complex (TSC)-associated and sporadic renal angiomyolipomas and other solid renal tumors. We also focus on radiologic interventions and molecular targeting of the TSC genetic pathway. CONCLUSION. Imaging plays a central role in the diagnosis and management of renal angiomyolipomas. It provides essential information to make the best therapeutic decisions about the interventional and pharmacologic options to help prevent bleeding and preserve functional parenchyma.
引用
收藏
页码：292 / 301
页数：10
相关论文
共 90 条
[1]   Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease [J].
Astrinidis, A ;
Henske, EP .
ONCOGENE, 2005, 24 (50) :7475-7481
[2]   Renal Angiomyolipoma Clinicopathologic Study of 194 Cases With Emphasis on the Epithelioid Histology and Tuberous Sclerosis Association [J].
Aydin, Hakan ;
Magi-Galluzzi, Cristina ;
Lane, Brian R. ;
Sercia, Linda ;
Lopez, Jose I. ;
Rini, Brian I. ;
Zhou, Ming .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2009, 33 (02) :289-297
[3]   The pathogenesis and imaging of the tuberous sclerosis complex [J].
Baskin, Henry J., Jr. .
PEDIATRIC RADIOLOGY, 2008, 38 (09) :936-952
[4]   Renal angiomyolipomata [J].
Bissler, JJ ;
Kingswood, JC .
KIDNEY INTERNATIONAL, 2004, 66 (03) :924-934
[5]   Reduction of postembolization syndrome after ablation of renal angiomyolipoma [J].
Bissler, JJ ;
Racadio, J ;
Donnelly, LF ;
Johnson, ND .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2002, 39 (05) :966-971
[6]   Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis [J].
Bissler, John J. ;
McCormack, Francis X. ;
Young, Lisa R. ;
Elwing, Jean M. ;
Chuck, Gail ;
Leonard, Jennifer M. ;
Schmithorst, Vincent J. ;
Laor, Tal ;
Brody, Alan S. ;
Bean, Judy ;
Salisbury, Shelia ;
Franz, David N. .
NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (02) :140-151
[7]   Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial [J].
Bissler, John J. ;
Kingswood, J. Christopher ;
Radzikowska, Elzbieta ;
Zonnenberg, Bernard A. ;
Frost, Michael ;
Belousova, Elena ;
Sauter, Matthias ;
Nonomura, Norio ;
Brakemeier, Susanne ;
de Vries, Petrus J. ;
Whittemore, Vicky H. ;
Chen, David ;
Sahmoud, Tarek ;
Shah, Gaurav ;
Lincy, Jeremie ;
Lebwohl, David ;
Budde, Klemens .
LANCET, 2013, 381 (9869) :817-824
[8]  
Bjornsson J, 1996, AM J PATHOL, V149, P1201
[9]   WFUMB safety symposium on ultrasound contrast agents: Clinical applications and safety concerns [J].
Blomley, Martin ;
Claudon, Michel ;
Cosgrove, David .
ULTRASOUND IN MEDICINE AND BIOLOGY, 2007, 33 (02) :180-186
[10]   CLEAR-CELL (SUGAR) TUMOR OF THE LUNG IS A LESION STRICTLY RELATED TO ANGIOMYOLIPOMA - THE CONCEPT OF A FAMILY OF LESIONS CHARACTERIZED BY THE PRESENCE OF THE PERIVASCULAR EPITHELIOID CELLS (PEG) [J].
BONETTI, F ;
PEA, M ;
MARTIGNONI, G ;
DOGLIONI, C ;
ZAMBONI, G ;
CAPELLI, P ;
RIMONDI, P ;
ANDRION, A .
PATHOLOGY, 1994, 26 (03) :230-236
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