Sigma1 receptor antagonists attenuate antidepressant-like effect induced by co-administration of 1,3 Di-o-tolylguanidine (DTG) and memantine in the forced swimming test in rats

被引：0
|
作者：
Skuza, GY [1 ]
Rogóz, Z [1 ]
机构：
[1] Polish Acad Sci, Inst Pharmacol, Dept Pharmacol, PL-31343 Krakow, Poland
来源：
POLISH JOURNAL OF PHARMACOLOGY | 2003年 / 55卷 / 06期
关键词：
sigma ligands; DTG; memantine; synergistic effect; progesterone; BD; 1047; forced swimming test; rats;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The obtained results show that DTG, the sigma(1)/sigma(2) receptor agonist, exerts a synergistic effect with memantine, an uncompetitive NMDA receptor antagonist, in the forced swimming test in rats, and that progesterone and BD 1047, the sigma(1) receptor antagonists, counteract this effect. The results suggest that the sigma(1) receptor subtype may contribute to the behavioral response induced by combined administration of DTG and memantine in Porsolt's test in rats.
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页码：1149 / 1152
页数：4
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