Multi-organ assessment in mainly non-hospitalized individuals after SARS-CoV-2 infection: The Hamburg City Health Study COVID programme

被引：113

作者：

Petersen, Elina Larissa ^{[1
,2
]}

Gossling, Alina ^{[1
,2
]}

Adam, Gerhard ^{[3
]}

Aepfelbacher, Martin ^{[4
]}

Behrendt, Christian-Alexander ^{[1
,2
]}

Cavus, Ersin ^{[1
,2
,5
]}

Cheng, Bastian ^{[6
]}

Fischer, Nicole ^{[4
]}

Gallinat, Juergen ^{[7
]}

Kuehn, Simone ^{[7
]}

Gerloff, Christian ^{[6
]}

Koch-Gromus, Uwe ^{[8
]}

Haerter, Martin ^{[8
]}

Hanning, Uta ^{[3
,9
]}

Huber, Tobias B. ^{[10
]}

Kluge, Stefan ^{[11
]}

Knobloch, Johannes K. ^{[4
]}

Kuta, Piotr ^{[12
]}

Schmidt-Lauber, Christian ^{[10
]}

Luetgehetmann, Marc ^{[4
]}

Magnussen, Christina ^{[1
,2
,5
]}

Mayer, Carola ^{[6
]}

Muellerleile, Kai ^{[1
,2
,5
]}

Muench, Julia ^{[1
,2
]}

Naegele, Felix Leonard ^{[6
]}

Petersen, Marvin ^{[6
]}

Renne, Thomas ^{[12
,13
,14
]}

Riedl, Katharina Alina ^{[1
,2
]}

Rimmele, David Leander ^{[6
]}

Schaefer, Ines ^{[1
,2
]}

Schulz, Holger ^{[8
]}

Tahir, Enver ^{[3
]}

Waschki, Benjamin ^{[1
,5
,15
,16
]}

Wenzel, Jan-Per ^{[1
,2
]}

Zeller, Tanja ^{[5
,17
]}

Ziegler, Andreas ^{[1
,18
,19
]}

Thomalla, Goetz ^{[6
]}

Twerenbold, Raphael ^{[1
,2
,5
,17
]}

Blankenberg, Stefan ^{[1
,2
,5
]}

机构：

[1] Univ Heart & Vasc Ctr, Dept Cardiol, Hamburg, Germany

[2] Univ Heart & Vasc Ctr, Populat Hlth Res Dept, Hamburg, Germany

[3] Univ Med Ctr Hamburg Eppendorf, Dept Diagnost & Intervent Radiol & Nucl Med, Hamburg, Germany

[4] Univ Med Ctr Hamburg Eppendorf, Inst Med Microbiol Virol & Hyg, Hamburg, Germany

[5] German Ctr Cardiovasc Res DZHK, Partner Site Hamburg Kiel Luebeck, Hamburg, Germany

[6] Univ Med Ctr Hamburg Eppendorf, Dept Neurol, Hamburg, Germany

[7] Univ Clin Hamburg Eppendorf, Clin & Policlin Psychiat & Psychotherapy, Hamburg, Germany

[8] Univ Med Ctr Hamburg Eppendorf UKE, Dept Med Psychol, Hamburg, Germany

[9] Univ Med Ctr Hamburg Eppendorf, Dept Diagnost & Intervent Neuroradiol, Hamburg, Germany

[10] Univ Med Ctr Hamburg Eppendorf, Dept Med 3, Hamburg, Germany

[11] Univ Med Ctr Hamburg Eppendorf, Dept Intens Care Med, Hamburg, Germany

[12] Univ Med Ctr Hamburg Eppendorf, Inst Clin Chem & Lab Med, Hamburg, Germany

[13] Johannes Gutenberg Univ Mainz, Med Ctr, Ctr Thrombosis & Hemostasis CTH, Mainz, Germany

[14] Royal Coll Surgeons Ireland, Irish Ctr Vasc Biol, Sch Pharm & Biomol Sci, Dublin, Ireland

[15] Hosp Itzehoe, Pneumol, Itzehoe, Germany

[16] LungenClin Grosshansdorf, German Ctr Lung Res DZL, Airway Res Ctr North ARCN, Grosshansdorf, Germany

[17] Univ Heart & Vasc Ctr, Univ Ctr Cardiovasc Sci, Hamburg, Germany

[18] Medizincampus Davos, Cardio Care, Davos, Switzerland

[19] Univ KwaZulu Natal, Sch Math Stat & Comp Sci, Pietermaritzburg, South Africa

来源：

EUROPEAN HEART JOURNAL | 2022年 / 43卷 / 11期

基金：

欧盟地平线“2020”;

关键词：

COVID-19; Sequelae; Matched controls; Multi-organ assessment; STANDARDIZATION;

D O I：

10.1093/eurheartj/ehab914

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims Long-term sequelae may occur after SARS-CoV-2 infection. We comprehensively assessed organ-specific functions in individuals after mild to moderate SARS-CoV-2 infection compared with controls from the general population. Methods and results Four hundred and forty-three mainly non-hospitalized individuals were examined in median 9.6 months after the first positive SARS-CoV-2 test and matched for age, sex, and education with 1328 controls from a population-based German cohort. We assessed pulmonary, cardiac, vascular, renal, and neurological status, as well as patient-related outcomes. Bodyplethysmography documented mildly lower total lung volume (regression coefficient -3.24, adjusted P = 0.014) and higher specific airway resistance (regression coefficient 8.11, adjusted P = 0.001) after SARS-CoV-2 infection. Cardiac assessment revealed slightly lower measures of left (regression coefficient for left ventricular ejection fraction on transthoracic echocardiography -0.93, adjusted P= 0.015) and right ventricular function and higher concentrations of cardiac biomarkers (factor 1.14 for high-sensitivity troponin, 1.41 for N-terminal pro-B-type natriuretic peptide, adjusted P <= 0.01) in post-SARS-CoV-2 patients compared with matched controls, but no significant differences in cardiac magnetic resonance imaging findings. Sonographically non-compressible femoral veins, suggesting deep vein thrombosis, were substantially more frequent after SARS-CoV-2 infection (odds ratio 2.68, adjusted P <0.001). Glomerular filtration rate (regression coefficient -2.35, adjusted P = 0.019) was lower in post-SARS-CoV-2 cases. Relative brain volume, prevalence of cerebral microbleeds, and infarct residuals were similar, while the mean cortical thickness was higher in post-SARS-CoV-2 cases. Cognitive function was not impaired. Similarly, patient-related outcomes did not differ. Conclusion Subjects who apparently recovered from mild to moderate SARS-CoV-2 infection show signs of subclinical multi- organ affection related to pulmonary, cardiac, thrombotic, and renal function without signs of structural brain damage, neurocognitive, or quality-of-life impairment. Respective screening may guide further patient management. [GRAPHICS] .

引用

页码：1124 / 1137

页数：14

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