Replication pattern in cancer: Asynchronous replication in multiple myeloma and in monoclonal gammopathy

被引：20

作者：

Amiel, A ^{[1
]}

Kirgner, I

Gaber, E

Manor, Y

Fejgin, M

Lishner, M

机构：

[1] Meir Gen Hosp, Genet Inst, IL-44281 Kefar Sava, Israel

[2] Meir Gen Hosp, Sapir Med Ctr, Dept Med, IL-44281 Kefar Sava, Israel

[3] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel

来源：

CANCER GENETICS AND CYTOGENETICS | 1999年 / 108卷 / 01期

关键词：

D O I：

10.1016/S0165-4608(98)00107-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this study we evaluated the replication pattern and cell-cycle dynamics of cells from patients considered to have a premalignant condition (monoclonal gammopathy, or MGUS) and patients with multiple myeloma (MM), as well as healthy controls. like applied the fluorescence in situ hybridization (FISH) technique with the TP53, RB-1 and 21q22 loci on the patient's cells. Asynchrony was determined by the presence of one single and one set of double dots in the same cell. The rare of asynchronic replication was significantly higher in the cells from MM patients, with intermediate value in the cells from MGUS, while the lowest rate was in cells from controls. We suggest that these results may reflect the changes in gene replication and cell-cycle progression that occur in premalignant and malignant cells. (C) Elsevier Science Inc., 1998.

引用

页码：32 / 37

页数：6

共 20 条

[1] Monoallelic p53 deletion in chronic lymphocytic leukemia detected by interphase cytogenetics [J].