Nanoparticles-based anti-aging treatment of Alzheimer's disease

被引：16
作者：
Chu, Jian-Jian [1 ,2 ]
Ji, Wen-Bo [1 ,2 ]
Zhuang, Jian-Hua [1 ]
Gong, Bao-Feng [1 ]
Chen, Xiao-Han [1 ]
Cheng, Wen-Bin [1 ]
Liang, Wen-Danqi [1 ]
Li, Gen-Ru [1 ]
Gao, Jie [2 ]
Yin, You [1 ]
机构：
[1] Naval Med Univ, Changzheng Hosp, Affiliated Hosp 2, Shanghai, Peoples R China
[2] Naval Med Univ, Shanghai Changhai Hosp, Changhai Clin Res Unit, Shanghai 200433, Peoples R China
来源：
DRUG DELIVERY | 2022年 / 29卷 / 01期
基金：
中国国家自然科学基金;
关键词：
AD; anti-aging; BBB; nanoparticles; senescent cells; anti-inflammation; BLOOD-BRAIN-BARRIER; AMYLOID-BETA; SENESCENT CELLS; ANTIINFLAMMATORY AGENTS; CELLULAR SENESCENCE; SECRETORY PHENOTYPE; COGNITIVE DEFICITS; GOLD NANOPARTICLES; TARGETED DELIVERY; MAMMALIAN TARGET;
D O I：
10.1080/10717544.2022.2094501
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Age is the strongest risk factor for Alzheimer's disease (AD). In recent years, the relationship between aging and AD has been widely studied, with anti-aging therapeutics as the treatment for AD being one of the mainstream research directions. Therapeutics targeting senescent cells have shown improvement in AD symptoms and cerebral pathological changes, suggesting that anti-aging strategies may be a promising alternative for AD treatment. Nanoparticles represent an excellent approach for efficiently crossing the blood-brain barrier (BBB) to achieve better curative function and fewer side effects. Thereby, nanoparticles-based anti-aging treatment may exert potent anti-AD therapeutic efficacy. This review discusses the relationship between aging and AD and the application and prospect of anti-aging strategies and nanoparticle-based therapeutics in treating AD.
引用
收藏
页码：2100 / 2116
页数：17
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