Molecular mechanisms of memory acquisition, consolidation and retrieval

被引：519
作者：
Abel, T [1 ]
Lattal, KM [1 ]
机构：
[1] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA
来源：
CURRENT OPINION IN NEUROBIOLOGY | 2001年 / 11卷 / 02期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S0959-4388(00)00194-X
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Memory is often considered to be a process that has several stages, including acquisition, consolidation and retrieval. Memory can be modified further through reconsolidation and performance can change during extinction trials while the original memory remains intact. Recent studies of the molecular basis of these processes have found that many signaling molecules are involved in several stages of memory but, in some cases, molecular pathways may be selectively recruited only during certain stages of memory.
引用
收藏
页码：180 / 187
页数：8
相关论文
共 63 条
[1]   Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory [J].
Abel, T ;
Nguyen, PV ;
Barad, M ;
Deuel, TAS ;
Kandel, ER .
CELL, 1997, 88 (05) :615-626
[2]   Positive and negative regulatory mechanisms that mediate long-term memory storage [J].
Abel, T ;
Kandel, E .
BRAIN RESEARCH REVIEWS, 1998, 26 (2-3) :360-378
[3]  
Anagnostaras SG, 1999, J NEUROSCI, V19, P1106
[4]   The NMDA antagonist MK-801 blocks the extinction of pavlovian fear conditioning [J].
Baker, JD ;
Azorlosa, JL .
BEHAVIORAL NEUROSCIENCE, 1996, 110 (03) :618-620
[5]   5-HT MODULATES PROTEIN-SYNTHESIS AND THE EXPRESSION OF SPECIFIC PROTEINS DURING LONG-TERM FACILITATION IN APLYSIA SENSORY NEURONS [J].
BARZILAI, A ;
KENNEDY, TE ;
SWEATT, JD ;
KANDEL, ER .
NEURON, 1989, 2 (06) :1577-1586
[6]   Involvement of hippocampal cAMP/cAMP-dependent protein kinase signaling pathways in a late memory consolidation phase of aversively motivated learning in rats [J].
Bernabeu, R ;
Bevilaqua, L ;
Ardenghi, P ;
Bromberg, E ;
Schmitz, P ;
Bianchin, M ;
Izquierdo, I ;
Medina, JH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (13) :7041-7046
[7]   Time-dependent reorganization of brain circuitry underlying long-term memory storage [J].
Bontempi, B ;
Laurent-Demir, C ;
Destrade, C ;
Jaffard, R .
NATURE, 1999, 400 (6745) :671-675
[8]  
Bourtchouladze R, 1998, LEARN MEMORY, V5, P365
[9]  
BOURTCHOULADZE R, 2000, SOC NEUR ABSTR, V26, P1500
[10]   CONTEXT, TIME, AND MEMORY RETRIEVAL IN THE INTERFERENCE PARADIGMS OF PAVLOVIAN LEARNING [J].
BOUTON, ME .
PSYCHOLOGICAL BULLETIN, 1993, 114 (01) :80-99
1234567