Bisphosphonate-related osteonecrosis of the maxilla and sinusitis maxillaris

被引：31

作者：

Maurer, P. ^{[1
]}

Sandulescu, T. ^{[1
]}

Kriwalsky, M. S. ^{[1
]}

Rashad, A. ^{[1
]}

Hollstein, S. ^{[1
]}

Stricker, I. ^{[2
]}

Hoelzle, F. ^{[3
]}

Kunkel, M. ^{[1
]}

机构：

[1] Ruhr Univ Bochum, Dept Oral & Plast Maxillofacial Surg, Bochum, Germany

[2] Ruhr Univ Bochum, Dept Pathol, Bochum, Germany

[3] Tech Univ Munich, Dept Oral & Plast Maxillofacial Surg, Munich, Germany

来源：

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY | 2011年 / 40卷 / 03期

关键词：

bisphosphonate; bisphosphonate-related osteonecrosis of the jaw; sinusitis maxillaris; cancer treatment; osteoporosis; RISK-FACTORS; JAW; BONE; MANAGEMENT; NECROSIS; CANCER; PAMIDRONATE; ASSOCIATION; INVOLVEMENT; ZOLEDRONATE;

D O I：

10.1016/j.ijom.2010.11.006

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Bisphosphonates (BPs) are widely used as bone-stabilizers, but side effects of BP therapy include bisphosphonate-related osteonecrosis of the jaw (BRONJ), which is resistant to therapy. The aim of this study was to evaluate the outcome of maxillary BRONJ involving sinusitis maxillaris. 21 patients presenting with maxillary BRONJ, from 2005 to 2008, were included in the study. In 18 cases BP had been administered for carcinoma and in 3 cases for osteoporosis, with an average exposure time of 47.4 months. 12 patients spontaneously developed BRONJ. The 10 patients diagnosed with stage III BRONJ presented with concomitant sinusitis maxillaris. Despite treatment, there were six recurrences of BRONJ, four of them with additional sinusitis maxillaris. Whether BRONJ occurred spontaneously or after extraction there was no difference in the outcome. Patients with advanced maxillary BRONJ often suffer from sinusitis maxillaris, both of which are frequently resistant to therapy.

引用

页码：285 / 291

页数：7

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