TERT-CLPTM1 locus polymorphism (rs401681) is associated with the prognosis of hepatocellular carcinoma

被引:4
作者
Lee, Hye Won [1 ]
Park, Won-Jin [2 ]
Heo, Yu-Ran [2 ]
Park, Tae In [3 ]
Park, Soo Young [4 ]
Lee, Jae-Ho [2 ]
机构
[1] Keimyung Univ, Sch Med, Dept Pathol, Daegu, South Korea
[2] Keimyung Univ, Sch Med, Dept Anat, 2800 Dalgubeoldaero, Daegu 42601, South Korea
[3] Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu, South Korea
[4] Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea
来源
ONCOTARGETS AND THERAPY | 2017年 / 10卷
基金
新加坡国家研究基金会;
关键词
CLPTM1L polymorphism; hepatocellular carcinoma; TERT-CLPTM1L locus; telomere length; TELOMERE LENGTH; SUSCEPTIBILITY LOCI; GENETIC-VARIATION; CANCER; 5P15.33; RISK; TERT;
D O I
10.2147/OTT.S138956
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Telomere length is associated with the development of hepatocellular carcinoma (HCC), and recent studies have focused on the genetic alteration or polymorphism in telomeremaintaining genes. We examined the clinicopathologic and prognostic value of rs401681 polymorphism, located in the TERT-CLPTM1L locus, in HCC. The relationship between rs401681 variants and telomere length was also analyzed in 156 HCC patients. The rs401681 polymorphism had the following genotype frequencies: C/C in 51.3% of the samples, C/T in 39.7%, and T/T in 9.0%. Telomeres in the tumor samples were 4.04-fold longer, on average, than the telomeres in matched normal samples (SD = 1.32), and there were no differences in telomere length according to rs401681 polymorphism (p= 0.802). Our results indicate that the rs401681 C allele was significantly associated with increased T and International Union for Cancer Control stages (p<0.01). Univariate and multivariate survival analyses showed that HCC with C allele had poorer prognosis (p<0.01). In conclusion, our findings suggest that rs401681 is a possible prognostic biomarker for HCC patients.
引用
收藏
页码:4853 / 4858
页数:6
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