Hindrance of the Proteolytic Activity of Neutrophil-Derived Serine Proteases by Serine Protease Inhibitors as a Management of Cardiovascular Diseases and Chronic Inflammation

被引：16

作者：

Burster, Timo ^{[1
]}

Mustafa, Zhadyra ^{[1
]}

Myrzakhmetova, Dinara ^{[1
]}

Zhanapiya, Anuar ^{[1
]}

Zimecki, Michal ^{[2
]}

机构：

[1] Nazarbayev Univ, Sch Sci & Humanities, Dept Biol, Nur Sultan, Kazakhstan

[2] Polish Acad Sci, Hirszfeld Inst Immunol & Expt Therapy, Wroclaw, Poland

来源：

FRONTIERS IN CHEMISTRY | 2021年 / 9卷

关键词：

serine protease inhibitors; serine proteases; neutrophil elastase; proteinase; 3; cathepsin G; thrombosis; SARS-CoV-2; COVID-19; CORONAVIRUS SPIKE PROTEIN; RESPIRATORY SYNDROME CORONAVIRUS; ANGIOTENSIN-II GENERATION; HOST-CELL ENTRY; CATHEPSIN-G; ELASTASE INHIBITOR; IN-VITRO; ALPHA-1-ANTITRYPSIN AUGMENTATION; ACTIVATED NEUTROPHILS; PLATELET-AGGREGATION;

D O I：

10.3389/fchem.2021.784003

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

During inflammation neutrophils become activated and segregate neutrophil serine proteases (NSPs) to the surrounding environment in order to support a natural immune defense. However, an excess of proteolytic activity of NSPs can cause many complications, such as cardiovascular diseases and chronic inflammatory disorders, which will be elucidated on a biochemical and immunological level. The application of selective serine protease inhibitors is the logical consequence in the management of the indicated comorbidities and will be summarized in this briefing.

引用

页数：19

共 201 条

[1] Augmented inflammatory responses and altered wound healing in cathepsin G-deficient mice [J].

Abbott, RE ;

Corral, CJ ;

MacIvor, DM ;

Lin, XH ;

Ley, TJ ;

Mustoe, TA .

ARCHIVES OF SURGERY, 1998, 133 (09) :1002-1006

[2] Boswellia serrata An Overall Assessment of In Vitro, Preclinical, Pharmacokinetic and Clinical Data [J].

Abdel-Tawab, Mona ;

Werz, Oliver ;

Schubert-Zsilavecz, Manfred .

CLINICAL PHARMACOKINETICS, 2011, 50 (06) :349-369

[3] Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage [J].

AhYoung, Andrew P. ;

Eckard, Sterling C. ;

Gogineni, Alvin ;

Xi, Hongkang ;

Lin, S. Jack ;

Gerhardy, Stefan ;

Cox, Christian ;

Phung, Qui T. ;

Hackney, Jason A. ;

Katakam, Anand Kumar ;

Reichelt, Mike ;

Caplazi, Patrick ;

Manzanillo, Paolo ;

Zhang, Juan ;

Roose-Girma, Merone ;

Tam, Lucinda W. ;

Newman, Robert J. ;

Murthy, Aditya ;

Weimer, Robby M. ;

Lill, Jennie R. ;

Lee, Wyne P. ;

Grimbaldeston, Michele ;

Kirchhofer, Daniel ;

Campagne, Menno van Lookeren .

COMMUNICATIONS BIOLOGY, 2020, 3 (01)

[4] Proteins associated with neutrophil degranulation are upregulated in nasopharyngeal swabs from SARS-CoV-2 patients [J].

Akgun, Emel ;

Tuzuner, Mete Bora ;

Sahin, Betul ;

Kilercik, Meltem ;

Kulah, Canan ;

Cakiroglu, Hacer Nur ;

Serteser, Mustafa ;

Unsal, Ibrahim ;

Baykal, Ahmet Tarik .

PLOS ONE, 2020, 15 (10)

[5] Neutrophil Elastase Promotes Interleukin-1β Secretion from Human Coronary Endothelium [J].

Alfaidi, Mabruka ;

Wilson, Heather ;

Daigneault, Marc ;

Burnett, Amanda ;

Ridger, Victoria ;

Chamberlain, Janet ;

Francis, Sheila .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (40) :24067-24078

[6] Single dose escalation studies with inhaled POL6014, a potent novel selective reversible inhibitor of human neutrophil elastase, in healthy volunteers and subjects with cystic fibrosis [J].

Barth, P. ;

Bruijnzeel, P. ;

Wach, A. ;

Kessler, O. Sellier ;

Hooftman, L. ;

Zimmermann, J. ;

Naue, N. ;

Huber, B. ;

Heimbeck, I. ;

Kappeler, D. ;

Timmer, W. ;

Chevalier, E. .

JOURNAL OF CYSTIC FIBROSIS, 2020, 19 (02) :299-304

[7] Human lactoferrin interacts with soluble CD14 and inhibits expression of endothelial adhesion molecules, E-selectin and ICAM-1, induced by the CD14-lipopolysaccharide complex [J].

Baveye, S ;

Elass, E ;

Fernig, DG ;

Blanquart, C ;

Mazurier, J ;

Legrand, D .

INFECTION AND IMMUNITY, 2000, 68 (12) :6519-6525

[8]

BELL D, 1990, BRIT HEART J, V63, P82

[9] Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites [J].

Belouzard, Sandrine ;

Chu, Victor C. ;

Whittaker, Gary R. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (14) :5871-5876

[10] TMPRSS2 Activates the Human Coronavirus 229E for Cathepsin-Independent Host Cell Entry and Is Expressed in Viral Target Cells in the Respiratory Epithelium [J].

Bertram, Stephanie ;

Dijkman, Ronald ;

Habjan, Matthias ;

Heurich, Adeline ;

Gierer, Stefanie ;

Glowacka, Ilona ;

Welsch, Kathrin ;

Winkler, Michael ;

Schneider, Heike ;

Hofmann-Winkler, Heike ;

Thiel, Volker ;

Poehlmann, Stefan .

JOURNAL OF VIROLOGY, 2013, 87 (11) :6150-6160

← 1 2 3 4 5 6 7 8 9 10 →