Stereoselective synthesis of allyl- and homoallylglycines

被引：17

作者：

Douat, C

Heitz, A

Martinez, J

Fehrentz, JA

机构：

[1] Univ Montpellier 1, Fac Pharm, CNRS, LAPP, F-34060 Montpellier, France

[2] Univ Montpellier 2, Fac Pharm, CNRS, LAPP, F-34060 Montpellier, France

[3] Fac Pharm Montpellier, CBS, UMI, CNRS,UMR5048, F-34060 Montpellier, France

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 19期

关键词：

allyglycine; homoallylglycine; Weinreb amide; aspartic acid; glutamic acid;

D O I：

10.1016/S0040-4039(01)00459-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method for the synthesis of N-protected allyl- and homoallylglycines was developed from aspartic and glutamic acid derivatives. The carboxylic side-chains of aspartic and glutamic derivatives was first transformed into the Weinreb amide by coupling with N,O-dimethylhydroxylamine and then reduced into the corresponding aldehyde. The latter could react with methyl-triphenylphosphonium bromide to yield the title compounds with 50% total yield. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：3319 / 3321

页数：3

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