Targeting Tumour Metastasis: The Emerging Role of Nanotechnology

被引:4
作者
Visentin, Sarah [1 ]
Sedic, Mirela [1 ]
Pavelic, Sandra Kraljevic [1 ]
Pavelic, Kresimir [2 ]
机构
[1] Univ Rijeka, Dept Biotechnol, Ctr High Throughput Technol, Radmile Matejcic 2, Rijeka, Croatia
[2] Juraj Dobrila Univ Pula, Fac Med, Zagrebacka 30, Pula 52100, Croatia
关键词
Metastasis; cancer stem cells; stem cell marker; nanomedicine; cancer therapy; nanotechnology; DENDRIMER-TEMPLATED ULTRASMALL; CANCER STEM-CELLS; IN-VIVO; DRUG-DELIVERY; ANTITUMOR-ACTIVITY; PHOTOTHERMAL ABLATION; PHOTODYNAMIC THERAPY; CARBON NANOTUBES; LUNG-CANCER; NANOPARTICLES;
D O I
10.2174/0929867326666181220095343
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The metastatic process has still not been completely elucidated, probably due to insufficient knowledge of the underlying mechanisms. Here, we provide an overview of the current findings that shed light on specific molecular alterations associated with metastasis and present novel concepts in the treatment of the metastatic process. In particular, we discuss novel pharmacological approaches in the clinical setting that target metastatic progression. New insights into the process of metastasis allow optimisation and design of new treatment strategies, especially in view of the fact that metastatic cells share common features with stem cells. Nano- and micro-technologies are herein elaborated in details as a promising therapeutic concept in targeted drug delivery for metastatic cancer. Progression in the field could provide a more efficient way to tackle metastasis and thus bring about advancements in the treatment and management of patients with advanced cancer.
引用
收藏
页码:1367 / 1381
页数:15
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