Targeting Tumour Metastasis: The Emerging Role of Nanotechnology

被引:4
作者
Visentin, Sarah [1 ]
Sedic, Mirela [1 ]
Pavelic, Sandra Kraljevic [1 ]
Pavelic, Kresimir [2 ]
机构
[1] Univ Rijeka, Dept Biotechnol, Ctr High Throughput Technol, Radmile Matejcic 2, Rijeka, Croatia
[2] Juraj Dobrila Univ Pula, Fac Med, Zagrebacka 30, Pula 52100, Croatia
关键词
Metastasis; cancer stem cells; stem cell marker; nanomedicine; cancer therapy; nanotechnology; DENDRIMER-TEMPLATED ULTRASMALL; CANCER STEM-CELLS; IN-VIVO; DRUG-DELIVERY; ANTITUMOR-ACTIVITY; PHOTOTHERMAL ABLATION; PHOTODYNAMIC THERAPY; CARBON NANOTUBES; LUNG-CANCER; NANOPARTICLES;
D O I
10.2174/0929867326666181220095343
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The metastatic process has still not been completely elucidated, probably due to insufficient knowledge of the underlying mechanisms. Here, we provide an overview of the current findings that shed light on specific molecular alterations associated with metastasis and present novel concepts in the treatment of the metastatic process. In particular, we discuss novel pharmacological approaches in the clinical setting that target metastatic progression. New insights into the process of metastasis allow optimisation and design of new treatment strategies, especially in view of the fact that metastatic cells share common features with stem cells. Nano- and micro-technologies are herein elaborated in details as a promising therapeutic concept in targeted drug delivery for metastatic cancer. Progression in the field could provide a more efficient way to tackle metastasis and thus bring about advancements in the treatment and management of patients with advanced cancer.
引用
收藏
页码:1367 / 1381
页数:15
相关论文
共 50 条
  • [1] Nanotechnology of emerging targeting systems
    Smith, S. S.
    MINERVA BIOTECNOLOGICA, 2008, 20 (03) : 127 - 131
  • [2] The Emerging Role of Ultrasonic Nanotechnology for Diagnosing and Treatment of Diseases
    Liu, Xinying
    Ge, Weidong
    FRONTIERS IN MEDICINE, 2022, 9
  • [3] The emerging role of cancer nanotechnology in the panorama of sarcoma
    Mercatali, Laura
    Vanni, Silvia
    Miserocchi, Giacomo
    Liverani, Chiara
    Spadazzi, Chiara
    Cocchi, Claudia
    Calabrese, Chiara
    Gurrieri, Lorena
    Fausti, Valentina
    Riva, Nada
    Genovese, Damiano
    Lucarelli, Enrico
    Focarete, Maria Letizia
    Ibrahim, Toni
    Calabro, Luana
    De Vita, Alessandro
    FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2022, 10
  • [4] Emerging Use of Nanotechnology in the Treatment of Neurological Disorders
    Chhabra, Resham
    Tosi, Giovanni
    Grabrucker, Andreas M.
    CURRENT PHARMACEUTICAL DESIGN, 2015, 21 (22) : 3111 - 3130
  • [5] Cancer Nanotechnology: Emerging Role of Gold Nanoconjugates
    Kudgus, Rachel A.
    Bhattacharya, Resham
    Mukherjee, Priyabrata
    ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2011, 11 (10) : 965 - 973
  • [6] Current and emerging concepts in tumour metastasis
    Coghlin, Caroline
    Murray, Graeme I.
    JOURNAL OF PATHOLOGY, 2010, 222 (01) : 1 - 15
  • [7] Stroke Management: An Emerging Role of Nanotechnology
    Sarmah, Deepaneeta
    Saraf, Jackson
    Kaur, Harpreet
    Pravalika, Kanta
    Tekade, Rakesh Kumar
    Borah, Anupom
    Kalia, Kiran
    Dave, Kunjan R.
    Bhattacharya, Pallab
    MICROMACHINES, 2017, 8 (09):
  • [8] Emerging nanomedicine-based strategies for preventing metastasis of pancreatic cancer
    Li, Yong-Jiang
    Wu, Jun-Yong
    Wang, Jie-Min
    Xiang, Da-Xiong
    JOURNAL OF CONTROLLED RELEASE, 2020, 320 : 105 - 111
  • [9] Nanotechnology applications in diagnosis and treatment of metastasis
    Sen Gupta, Anirban
    NANOMEDICINE, 2014, 9 (10) : 1517 - 1529
  • [10] Emerging Applications of Nanotechnology in Healthcare and Medicine
    Malik, Shiza
    Muhammad, Khalid
    Waheed, Yasir
    MOLECULES, 2023, 28 (18):