Phylogenetic Diversity of Orientia tsutsugamushi Isolates in Patients with Scrub Typhus in Bengaluru, India

被引：10

作者：

Chunchanur, Sneha K. ^{[1
]}

Venugopal, Shwetha J. ^{[1
]}

Ambica, R. ^{[1
]}

Dakshayani, B. ^{[2
]}

机构：

[1] Victoria Hosp, Bangalore Med Coll & Res Inst, Dept Microbiol, Ft KR Rd, Bengaluru 560002, Karnataka, India

[2] Victoria Hosp, Bangalore Med Coll & Res Inst, Dept Paediat, Bengaluru, Karnataka, India

来源：

INDIAN JOURNAL OF MEDICAL MICROBIOLOGY | 2019年 / 37卷 / 03期

关键词：

Orientia tsutsugamushi; phylogenetic analysis; polymerase chain reaction; scrub typhus; GENOTYPE;

D O I：

10.4103/ijmm.IJMM_19_267

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Scrub typhus has re-emerged as an important cause of acute febrile illness in India. There is a dearth of information on strain diversity of Orientia tsutsugamushi from Karnataka, India, hence the present study sought to address this issue. One hundred clinically suspected cases of scrub typhus/rickettsiosis (as per the DHR-ICMR guidelines) were included. Nested-polymerase chain reaction (PCR) for 56-kDa gene and phylogenetic analysis was performed. PCR was positive in 22 cases and phylogenetic analysis showed the presence of different strains, with predominance of clustering (57%) with Gilliam-type for the first time in Karnataka. Knowledge of genetic diversity has implications in development of diagnostics and vaccine.

引用

页码：438 / 441

页数：4

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