The Role of Human Leukocyte Antigen in Celiac Disease Diagnostics

被引：13

作者：

Lazar-Molnar, Eszter ^{[1
]}

Snyder, Melissa ^{[2
]}

机构：

[1] Univ Utah, Sch Med, Dept Pathol, ARUP Labs, 500 Chipeta Way,MS 115, Salt Lake City, UT 84108 USA

[2] Mayo Clin, Dept Lab Med & Pathol, 200 First St Southwest, Rochester, MN 55905 USA

来源：

CLINICS IN LABORATORY MEDICINE | 2018年 / 38卷 / 04期

关键词：

Celiac disease; HLA-DQ2; HLA-DQ8; Disease association; EUROPEAN GENETICS CLUSTER; GENOME-WIDE ASSOCIATION; TISSUE TRANSGLUTAMINASE; UNITED-STATES; T-CELLS; AT-RISK; ANTIBODY; GLUTEN; IDENTIFICATION; PREVALENCE;

D O I：

10.1016/j.cll.2018.07.007

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Celiac disease is an autoimmune disease affecting the small intestine, triggered by gluten sensitization in genetically susceptible individuals worldwide. Celiac disease development is strongly linked to the presence of HLA-DQ2 and/or DQ8, which present the immunogenic gluten peptides and trigger the immune response leading to pathogenesis. Because of the variability of clinical symptoms, the disease is often underdiagnosed. Intestinal biopsy and the presence of antibodies to deamidated gliadin and tissue transglutaminase are recommended diagnostic tools. Genetic testing for HLA DQ2 and DQ8 can be used to rule out disease in at-risk populations.

引用

页码：655 / 668

页数：14

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