Approaches to Establishing Tolerance in Immune Mediated Diseases

被引：11
|
作者：
Huffaker, Michelle F. [1 ]
Sanda, Srinath [1 ]
Chandran, Sindhu [1 ]
Chung, Sharon A. [1 ]
St Clair, E. William [2 ]
Nepom, Gerald T. [3 ]
Smilek, Dawn E. [1 ]
机构：
[1] Univ Calif San Francisco, Immune Tolerance Network, San Francisco, CA 94143 USA
[2] Duke Univ, Immune Tolerance Network, Durham, NC USA
[3] Benaroya Res Inst, Immune Tolerance Network, Seattle, WA USA
来源：
FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷
基金：
美国国家卫生研究院;
关键词：
immune tolerance; allergy; transplantation; autoimmunity; clinical trial; immunomodulation; immunosuppression; STEM-CELL TRANSPLANTATION; DOSE IMMUNOSUPPRESSIVE THERAPY; BONE-MARROW-TRANSPLANTATION; B-LYMPHOCYTE DEPLETION; MULTIPLE-SCLEROSIS; T-CELLS; RANDOMIZED-TRIAL; LUPUS NEPHRITIS; DOUBLE-BLIND; RITUXIMAB;
D O I：
10.3389/fimmu.2021.744804
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The development of rational approaches to restore immune tolerance requires an iterative approach that builds on past success and utilizes new mechanistic insights into immune-mediated pathologies. This article will review concepts that have evolved from the clinical trial experience of the Immune Tolerance Network, with an emphasis on lessons learned from the innovative mechanistic studies conducted for these trials and new strategies under development for induction of tolerance.
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页数：10
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