Modification of polylactic acid surface using RF plasma discharge with sputter deposition of a hydroxyapatite target for increased biocompatibility

被引：45

作者：

Tverdokhlebov, S. I. ^{[1
]}

Bolbasov, E. N. ^{[1
]}

Shesterikov, E. V. ^{[1
]}

Antonova, L. V. ^{[2
]}

Golovkin, A. S. ^{[2
]}

Matveeva, V. G. ^{[2
]}

Petlin, D. G. ^{[3
]}

Anissimov, Y. G. ^{[3
]}

机构：

[1] Tomsk Polytech Univ, Tomsk 634050, Russia

[2] Fed State Budgetary Inst Res Inst Complex Issues, Kemerovo 650002, Russia

[3] Griffith Univ, Sch Nat Sci, Southport, Qld 4222, Australia

来源：

APPLIED SURFACE SCIENCE | 2015年 / 329卷

基金：

俄罗斯基础研究基金会;

关键词：

Polylactic acid; Biomaterial; Biocompatibility; Magnetron sputter deposition; Calcium-phosphate; CALCIUM-PHOSPHATE COATINGS; MULTIPLE MELTING BEHAVIOR; L-LACTIC ACID; POLY(L-LACTIC ACID); IMPLANT SURFACES; CRYSTALLIZATION; POLYMERS; POLYETHYLENE; CONFORMATION; RECOGNITION;

D O I：

10.1016/j.apsusc.2014.12.127

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Surface modification of polylactic acid (PLLA) by plasma of radio-frequency magnetron discharge with hydroxyapatite target sputtering was investigated. Increased biocompatibility was demonstrated using studies with bone marrow multipotent mesenchymal stromal cells. Atomic force microscopy demonstrates that the plasma treatment modifies the surface morphology of PLLA to produce rougher surface. Infrared spectroscopy and X-ray diffraction revealed that changes in the surface morphology are caused by the processes of PLLA crystallization. Fluorescent X-ray spectroscopy showed that the plasma treatment also changes the chemical composition of PLLA, enriching it with ions of the sputtered target: calcium, phosphorus and oxygen. It is hypothesized that these surface modifications increase biocompatibility of PLLA without increasing toxicity. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：32 / 39

页数：8

共 40 条

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