HIF-1 and mechanisms of hypoxia sensing

被引：1065

作者：

Semenza, GL ^{[1
]}

机构：

[1] Johns Hopkins Hosp, Baltimore, MD 21287 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2001年 / 13卷 / 02期

关键词：

D O I：

10.1016/S0955-0674(00)00194-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Hypoxia-inducible factor 1 (HIF-1) is an oxygen-regulated transcriptional activator that plays essential roles in mammalian development, physiology and disease pathogenesis. The HIF-1 a subunit is subjected to oxygen-dependent ubiquitination and proteasomal degradation that is mediated by the von Hippel-Lindau protein. Interaction of HIF-1 alpha transactivation domains with coactivators is induced by hypoxia. The signal transduction pathway remains enigmatic, but involves generation of reactive oxygen species. Nitric oxide induces HIF-1 alpha under non-hypoxic conditions but inhibits hypoxia-induced HIF-1 alpha expression.

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收藏

页码：167 / 171

页数：5

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