Inflammasome Inhibition: Putting Out the Fire

被引：27

作者：

Netea, Mihai G. ^{[1
,2
]}

Joosten, Leo A. B. ^{[1
,2
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, NL-6525 ED Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Radboud Ctr Infect Dis, NL-6525 ED Nijmegen, Netherlands

来源：

CELL METABOLISM | 2015年 / 21卷 / 04期

关键词：

NLRP3; INFLAMMASOME; FATTY-ACIDS; ACTIVATION;

D O I：

10.1016/j.cmet.2015.03.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

NLRP3-inflammasome activates caspase-1 and processes pro-IL-1 beta and pro-IL-18 into the active cytokines. Two recent studies describe specific inhibitors of NLRP3 inflammasome that inhibit IL-1 beta release and inflammation. The specificity and potency of these compounds gives hope that a targeted approach to inhibit NLRP3-driven inflammation may be just around the corner.

引用

页码：513 / 514

页数：2

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