Ratiometric Detection of H2S in Liver Injury by Activated Two-Wavelength Photoacoustic Imaging

被引:29
作者
Wu, Rongrong [1 ]
Chen, Zhongxiang [1 ]
Huo, Hongqi [2 ]
Chen, Lanlan [1 ]
Su, Lichao [1 ]
Zhang, Xuan [1 ]
Wu, Ying [1 ]
Yao, Zhicun [1 ]
Xiao, Shenggan [1 ]
Du, Wei [1 ]
Song, Jibin [1 ]
机构
[1] Fuzhou Univ, Coll Chem, Coll Chem Engn,MOE Key Lab Analyt Sci Food Safety, Fujian Sci & Technol Innovat Lab Optoelect Informa, R China, Fuzhou 350108, Peoples R China
[2] Han Dan Cent Hosp, Dept Nucl Med, Handan 056001, Hebei, Peoples R China
基金
中国国家自然科学基金;
关键词
HYDROGEN-SULFIDE; UP-REGULATION; METFORMIN; PROBE; THERAPY;
D O I
10.1021/acs.analchem.2c01571
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Metformin is commonly used for clinical treatment of type-2 diabetes, but long-term or overdose intake of metformin usually causes selective upregulation of H2S level in the liver, resulting in liver injury. Therefore, tracking the changes of H2S content in the liver would contribute to the prevention and diagnosis of liver injury. However, in the literature, there are few reports on ratiometric PA molecular probes for H2S detection in drug-induced liver injury (DILI). Accordingly, here we developed a H2S-activated ratiometric PA probe, namely BDP-H2S, based Aza-BODIPY dye for detecting the H2S upregulation of metformin-induced liver injury. Due to the intramolecular charge transfer (ICT) effect, BDP-H2S exhibited a strong PA signal at 770 nm. Following the response to H2S, its ICT effect was recovered which showed a decrement of PA(7)(70) and an enhancement of PA(840). The ratiometric PA signal (PA(840)/PA(7)(70)) showed excellent H2S selectivity response with a low limit of detection (0.59 mu M). Bioimaging experiments demonstrated that the probe has been successfully used for ratiometric PA imaging of H2S in cells and metformin-induced liver injury in mice. Overall, the designed probe emerges as a powerful tool for noninvasive and accurate imaging of H2S level and tracking its distribution and variation in liver in-real time.
引用
收藏
页码:10797 / 10804
页数:8
相关论文
共 42 条
[1]   Recent Progress in Fluorescent Sensors for Drug-Induced Liver Injury Assessment [J].
Chen, Jiao ;
Huang, Dongyu ;
She, Mengyao ;
Wang, Zesi ;
Chen, Xi ;
Liu, Ping ;
Zhang, Shengyong ;
Li, Jianli .
ACS SENSORS, 2021, 6 (03) :628-640
[2]   An Optical/Photoacoustic Dual-Modality Probe: Ratiometric in/ex Vivo Imaging for Stimulated H2S Upregulation in Mice [J].
Chen, Zhongyan ;
Mu, Xueling ;
Han, Zhong ;
Yang, Shiping ;
Zhang, Changli ;
Guo, Zijian ;
Bai, Yang ;
He, Weijiang .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2019, 141 (45) :17973-17977
[3]   Design Strategy of Fluorescent Probes for Live Drug-Induced Acute Liver Injury Imaging [J].
Cheng, Dan ;
Xu, Wang ;
Gong, Xiangyang ;
Yuan, Lin ;
Zhang, Xiao-Bing .
ACCOUNTS OF CHEMICAL RESEARCH, 2021, 54 (02) :403-415
[4]   Hepatotoxicity Associated with Metformin Therapy in Treatment of Type 2 Diabetes Mellitus with Nonalcoholic Fatty Liver Disease [J].
Cone, Catherine J. ;
Bachyrycz, Amy M. ;
Murata, Glen H. .
ANNALS OF PHARMACOTHERAPY, 2010, 44 (10) :1655-1659
[5]   Clinical Outcomes of Metformin Use in Populations With Chronic Kidney Disease, Congestive Heart Failure, or Chronic Liver Disease A Systematic Review [J].
Crowley, Matthew J. ;
Diamantidis, Clarissa J. ;
McDuffie, Jennifer R. ;
Cameron, C. Blake ;
Stanifer, John W. ;
Mock, Clare K. ;
Wang, Xianwei ;
Tang, Shuang ;
Nagi, Avishek ;
Kosinski, Andrzej S. ;
Williams, John W., Jr. .
ANNALS OF INTERNAL MEDICINE, 2017, 166 (03) :191-+
[6]   Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss [J].
Day, Emily A. ;
Ford, Rebecca J. ;
Smith, Brennan K. ;
Mohammadi-Shemirani, Pedrum ;
Morrow, Marisa R. ;
Gutgesell, Robert M. ;
Lu, Rachel ;
Raphenya, Amogelang R. ;
Kabiri, Mostafa ;
McArthur, Andrew G. ;
McInnes, Natalia ;
Hess, Sibylle ;
Pare, Guillaume ;
Gerstein, Hertzel C. ;
Steinberg, Gregory R. .
NATURE METABOLISM, 2019, 1 (12) :1202-+
[7]   Endogenous H2S-Activated Orthogonal Second Near-Infrared Emissive Nanoprobe for In Situ Ratiometric Fluorescence Imaging of Metformin-Induced Liver Injury [J].
Deng, Zhiming ;
Bi, Shenghui ;
Jiang, Mingyang ;
Zeng, Songjun .
ACS NANO, 2021, 15 (02) :3201-3211
[8]   A photoacoustic Zn2+ sensor based on a merocyanine/xanthene-6-ol hybrid chromophore and its ratiometric imaging in mice [J].
Fang, Hongbao ;
Wang, Chengjun ;
Chen, Yuncong ;
Chen, Zhongyan ;
Yao, Shankun ;
Yang, Shiping ;
Dong, Lei ;
Guo, Zijian ;
He, Weijiang .
INORGANIC CHEMISTRY FRONTIERS, 2021, 8 (13) :3402-3410
[9]   NIR-II Photoacoustic Reporter for Biopsy-Free and Real-Time Assessment of Wilson's Disease [J].
Fu, Qinrui ;
Ye, Jiamin ;
Wang, Juejun ;
Liao, Naishun ;
Feng, Hongjuan ;
Su, Lichao ;
Ge, Xiaoguang ;
Yang, Huanghao ;
Song, Jibin .
SMALL, 2021, 17 (26)
[10]   Magnetic targeted near-infrared II PA/MR imaging guided photothermal therapy to trigger cancer immunotherapy [J].
Fu, Qinrui ;
Li, Zhi ;
Ye, Jiamin ;
Li, Zhong ;
Fu, Fengfu ;
Lin, Syue-Liang ;
Chang, Cheng Allen ;
Yang, Huanghao ;
Song, Jibin .
THERANOSTICS, 2020, 10 (11) :4997-5010