Non-atheromatous arterial stenoses in atypical haemolytic uraemic syndrome associated with complement dysregulation

被引：30

作者：

Loirat, Chantal ^{[1
]}

Macher, Marie-Alice ^{[1
]}

Elmaleh-Berges, Monique

Kwon, Theresa ^{[1
]}

Deschenes, Georges ^{[1
]}

Goodship, Timothy H. J. ^{[2
]}

Majoie, Charles ^{[3
]}

Davin, Jean-Claude ^{[4
]}

Blanc, Raphael ^{[5
]}

Savatovsky, Julien ^{[6
]}

Moret, Jacques

Fremeaux-Bacchi, Veronique ^{[7
]}

机构：

[1] Univ Paris 07, Hop Robert Debre, AP HP, Pediat Nephrol Dept, Paris, France

[2] Newcastle Univ, Inst Human Genet, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[3] Univ Amsterdam, Acad Med Ctr, Dept Radiol, NL-1105 AZ Amsterdam, Netherlands

[4] Emma Childrens Hosp, Pediat Nephrol Dept, Amsterdam, Netherlands

[5] Fdn Ophtalmol Adolphe de Rothschild, Intervent Neuroradiol Dept, Paris, France

[6] Fdn Ophtalmol Adolphe de Rothschild, Dept Med Imaging, Paris, France

[7] Hop Europeen Georges Pompidou, AP HP, Biol Immunol Dept, Paris, France

来源：

NEPHROLOGY DIALYSIS TRANSPLANTATION | 2010年 / 25卷 / 10期

关键词：

angioplasty; arterial stenosis; atypical haemolytic uraemic syndrome; complement factor B; complement factor H; CARDIOVASCULAR-DISEASE; FACTOR-H; ECULIZUMAB; ATHEROSCLEROSIS; MUTATIONS; CHILDREN; IMPACT; CELLS; CD59; CKD;

D O I：

10.1093/ndt/gfq319

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

Results. Stenoses of both carotid arteries, left subclavian and vertebral arteries, several intracranial, right humeral, several coronary, and all pulmonary arteries were demonstrated. At the age of 13 years, left subclavian and right cervical carotid arteries were occluded. Right carotid recanalization induced intracranial dissection and death. The child had a Lys350Asp factor B mutation. Conclusion. Arterial steno-occlusive lesions appear as potential complications of dysregulated complement activation in aHUS. Endovascular treatment should be considered cautiously in this setting.

引用

页码：3421 / 3425

页数：5

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