Taste Genes Associated with Dental Caries

被引：110

作者：

Wendell, S. ^{[1
,2
]}

Wang, X. ^{[1
]}

Brown, M. ^{[1
]}

Cooper, M. E. ^{[1
]}

DeSensi, R. S. ^{[1
]}

Weyant, R. J. ^{[2
,4
]}

Crout, R. ^{[2
,3
]}

McNeil, D. W. ^{[2
]}

Marazita, M. L. ^{[1
,2
,5
]}

机构：

[1] Univ Pittsburgh, Sch Dent Med, Dept Oral Biol, Ctr Craniofacial & Dent Genet, Pittsburgh, PA 15219 USA

[2] Univ Pittsburgh, Ctr Oral Hlth Res Appalachia, Pittsburgh, PA 15219 USA

[3] W Virginia Univ, Dept Periodont, Sch Dent, Morgantown, WV 26506 USA

[4] Univ Pittsburgh, Dept Dent Publ Hlth & Informat Management, Sch Dent Med, Pittsburgh, PA 15219 USA

[5] Univ Pittsburgh, Dept Human Genet, Grad Sch Publ Hlth, Pittsburgh, PA 15219 USA

来源：

JOURNAL OF DENTAL RESEARCH | 2010年 / 89卷 / 11期

关键词：

dental caries; taste preference; genetic association; taste pathway genes; BITTER-TASTE; 6-N-PROPYLTHIOURACIL; SENSITIVITY; HERITABILITY; STRATEGIES; CHILDREN;

D O I：

10.1177/0022034510381502

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Dental caries is influenced by a complex interplay of genetic and environmental factors, including dietary habits. Previous reports have characterized the influence of genetic variation on taste preferences and dietary habits. We therefore hypothesized that genetic variation in taste pathway genes (TAS2R38, TAS1R2, GNAT3) may be associated with dental caries risk and/or protection. Families were recruited by the Center for Oral Health Research in Appalachia (COHRA) for collection of biological samples, demographic data, and clinical assessment of oral health, including caries scores. Multiple single-nucleotide polymorphism (SNP) assays for each gene were performed and analyzed by transmission disequilibrium test (TDT) analysis (FBAT software) for three dentition groups: primary, mixed, and permanent. Statistically significant associations were seen in TAS2R38 and TAS1R2 for caries risk and/or protection.

引用

页码：1198 / 1202

页数：5

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