Mortality Resulting From Congenital Heart Disease Among Children and Adults in the United States, 1999 to 2006

被引:415
作者
Gilboa, Suzanne M. [1 ]
Salemi, Jason L. [2 ]
Nembhard, Wendy N. [2 ]
Fixler, David E. [3 ]
Correa, Adolfo [1 ]
机构
[1] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA
[2] Univ S Florida, Coll Publ Hlth, Dept Epidemiol & Biostat, Tampa, FL USA
[3] Univ Texas SW Med Ctr Dallas, Div Cardiol, Dept Pediat, Dallas, TX 75390 USA
关键词
epidemiology; heart defects; congenital; mortality; race; vital statistics; BIRTH-DEFECTS; PRENATAL-DIAGNOSIS; METROPOLITAN ATLANTA; INFANT-MORTALITY; 1ST-YEAR SURVIVAL; GREAT-ARTERIES; YOUNG-ADULT; POPULATION; TRENDS; PREVALENCE;
D O I
10.1161/CIRCULATIONAHA.110.947002
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background-Previous reports suggest that mortality resulting from congenital heart disease (CHD) among infants and young children has been decreasing. There is little population-based information on CHD mortality trends and patterns among older children and adults. Methods and Results-We used data from death certificates filed in the United States from 1999 to 2006 to calculate annual CHD mortality by age at death, race-ethnicity, and sex. To calculate mortality rates for individuals >= 1 year of age, population counts from the US Census were used in the denominator; for infant mortality, live birth counts were used. From 1999 to 2006, there were 41 494 CHD-related deaths and 27 960 deaths resulting from CHD (age-standardized mortality rates, 1.78 and 1.20 per 100 000, respectively). During this period, mortality resulting from CHD declined 24.1% overall. Mortality resulting from CHD significantly declined among all race-ethnicities studied. However, disparities persisted; overall and among infants, mortality resulting from CHD was consistently higher among non-Hispanic blacks compared with non-Hispanic whites. Infant mortality accounted for 48.1% of all mortality resulting from CHD; among those who survived the first year of life, 76.1% of deaths occurred during adulthood (>= 18 years of age). Conclusions-CHD mortality continued to decline among both children and adults; however, differences between race-ethnicities persisted. A large proportion of CHD-related mortality occurred during infancy, although significant CHD mortality occurred during adulthood, indicating the need for adult CHD specialty management. (Circulation. 2010;122:2254-2263.)
引用
收藏
页码:2254 / 2263
页数:10
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