Diagnosis and treatment of iron deficiency in patients with heart failure: Expert position paper from French cardiologists

被引：27

作者：

Cohen-Solal, Alain ^{[1
]}

Leclercq, Christophe ^{[2
]}

Mebazaa, Alexandre ^{[3
]}

De Groote, Pascal ^{[4
]}

Damy, Thibaud ^{[5
]}

Isnard, Richard ^{[6
]}

Galinier, Michel ^{[7
]}

机构：

[1] Univ Paris Diderot, UMR S 942, DHU FIRE, Dept Cardiol,Lariboisiere Hosp,AP HP, F-75010 Paris, France

[2] Pontchaillou Hosp, Dept Cardiol & Vasc Dis, F-35033 Rennes, France

[3] Univ Paris Diderot, UMR S 942, Dept Anaesthesia & Crit Care Med, DHU Neurovasc,Lariboisiere Hosp,AP HP, F-75010 Paris, France

[4] CHRU Lille, Cardiol Hosp, Dept Cardiol, F-59037 Lille, France

[5] Univ Paris Est, INSERM U955, DHU ATM, Dept Cardiol,Henri Mondor Hosp,AP HP, F-94000 Creteil, France

[6] Univ Paris 06, Pitie Salpetriere Hosp, AP HP, Dept Cardiol, F-75005 Paris, France

[7] Univ Toulouse, CHU Rangueil, Dept Cardiol, UMR 1048, F-31059 Toulouse, France

来源：

ARCHIVES OF CARDIOVASCULAR DISEASES | 2014年 / 107卷 / 10期

关键词：

Heart failure; Iron deficiency; Intravenous iron; Serum ferritin; Transferrin saturation; INTRAVENOUS IRON; EXERCISE TOLERANCE; CHRONIC DISEASE; TASK-FORCE; ANEMIA; SUPPLEMENTATION; ERYTHROPOIETIN; INSUFFICIENCY; HOMEOSTASIS; GUIDELINES;

D O I：

10.1016/j.acvd.2014.07.049

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The prevalence of iron deficiency is high - even in the absence of anaemia - in patients with chronic heart failure (HF). Although iron deficiency is easily diagnosed with two biomarkers (serum ferritin and transferrin saturation), it is underdiagnosed in patients with HE Iron is not only necessary for red blood cells, but also for cells in tissues with high-energy demands (heart, muscle, brain). Even before the onset of anaemia, HF patients with iron deficiency have decreased physical and cognitive performances and a poorer quality of life. Moreover, iron deficiency is a risk factor, independent of anaemia, of unfavourable outcome (death or heart transplantation) in patients with chronic HF. Several randomized controlled studies have shown improvement in exercise capacity, New York Heart Association functional class and quality of life after correction of iron deficiency. The results of these clinical trials, which are supported by European guidelines, suggest considering iron deficiency in HF as a possible therapeutic target. (C) 2014 Published by Elsevier Masson SAS.

引用

页码：563 / 571

页数：9

共 36 条

[21] Myocardial and Systemic Iron Depletion in Heart Failure Implications for Anemia Accompanying Heart Failure [J].

Maeder, Micha T. ;

Khammy, Ouda ;

dos Remedios, Cris ;

Kaye, David M. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2011, 58 (05) :474-480

[22] ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012 The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC [J].

McMurray, John J. V. ;

Adamopoulos, Stamatis ;

Anker, Stefan D. ;

Auricchio, Angelo ;

Boehm, Michael ;

Dickstein, Kenneth ;

Falk, Volkmar ;

Filippatos, Gerasimos ;

Fonseca, Candida ;

Gomez-Sanchez, Miguel Angel ;

Jaarsma, Tiny ;

Kober, Lars ;

Lip, Gregory Y. H. ;

Maggioni, Aldo Pietro ;

Parkhomenko, Alexander ;

Pieske, Burkert M. ;

Popescu, Bogdan A. ;

Ronnevik, Per K. ;

Rutten, Frans H. ;

Schwitter, Juerg ;

Seferovic, Petar ;

Stepinska, Janina ;

Trindade, Pedro T. ;

Voors, Adriaan A. ;

Zannad, Faiez ;

Zeiher, Andreas .

EUROPEAN JOURNAL OF HEART FAILURE, 2012, 14 (08) :803-869

[23] Iron treatment normalizes cognitive functioning in young women [J].

Murray-Kolb, Laura E. ;

Beard, John L. .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2007, 85 (03) :778-787

[24] Etiology of anemia in patients with advanced heart failure [J].

Nanas, John N. ;

Matsouka, Charis ;

Karageorgopoulos, Drosos ;

Leonti, Anastasia ;

Tsolakis, Elias ;

Drakos, Stavros G. ;

Tsagalou, Eleftheria P. ;

Maroulidis, George D. ;

Alexopoulos, George P. ;

Kanakakis, John E. ;

Anastasiou-Nana, Maria I. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 48 (12) :2485-2489

[25] Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein [J].

Nemeth, E ;

Valore, EV ;

Territo, M ;

Schiller, G ;

Lichtenstein, A ;

Ganz, T .

BLOOD, 2003, 101 (07) :2461-2463

[26] Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency [J].

Okonko, Darlington O. ;

Grzeslo, Agnieszka ;

Witkowski, Tomasz ;

Mandal, Amit K. J. ;

Slater, Robert M. ;

Roughton, Michael ;

Foldes, Gabor ;

Thum, Thomas ;

Majda, Jacek ;

Banasiak, Waldemar ;

Missouris, Constantinos G. ;

Poole-Wilson, Philip A. ;

Anker, Stefan D. ;

Ponikowski, Piotr .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 51 (02) :103-112

[27] Disordered Iron Homeostasis in Chronic Heart Failure Prevalence, Predictors, and Relation to Anemia, Exercise Capacity, and Survival [J].

Okonko, Darlington O. ;

Mandal, Amit K. J. ;

Missouris, Constantinos G. ;

Poole-Wilson, Philip A. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2011, 58 (12) :1241-1251

[28] Blunted erythropoietin production and defective iron supply for erythropoiesis as major causes of anaemia in patients with chronic heart failure [J].

Opasich, C ;

Cazzola, M ;

Scelsi, L ;

De Feo, S ;

Bosimini, E ;

Lagioia, R ;

Febo, O ;

Ferrari, R ;

Fucili, A ;

Moratti, R ;

Tramarin, R ;

Tavazzi, L .

EUROPEAN HEART JOURNAL, 2005, 26 (21) :2232-2237

[29] Altered intestinal function in patients with chronic heart failure [J].

Sandek, Anja ;

Bauditz, Juergen ;

Swidsinski, Alexander ;

Buhner, Sabine ;

Weber-Eibel, Jutta ;

von Haehling, Stephan ;

Schroedl, Wieland ;

Karhausen, Tim ;

Doehner, Wolfram ;

Rauchhaus, Mathias ;

Poole-Wilson, Philip ;

Volk, Hans-Dieter ;

Lochs, Herbert ;

Anker, Stefan D. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 50 (16) :1561-1569

[30] Intravenous iron reduces NT-Pro-Brain natriuretic peptide in anemic patients with chronic heart failure and renal insufficiency [J].

Toblli, Jorge Eduardo ;

Lombrana, Alejandra ;

Duarte, Patricio ;

Di Germaro, Federico .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 50 (17) :1657-1665

← 1 2 3 4 →