Fetal Programming: Early-life Modulations that Affect Adult Outcomes

被引:25
作者
Drever, Nathan [1 ]
Saade, George R. [1 ]
Bytautiene, Egle [1 ]
机构
[1] Univ Texas Galveston, Med Branch, Div Maternal Fetal Med, Dept Obstet & Gynecol, Galveston, TX 77555 USA
关键词
Asthma; Fetal programming; Offspring; Epigenetics; LOW-BIRTH-WEIGHT; MATERNAL SMOKING; ALLERGIC SENSITIZATION; LUNG-FUNCTION; IN-UTERO; VITAMIN-E; ASTHMA; EXPOSURE; ASSOCIATION; DISEASE;
D O I
10.1007/s11882-010-0136-9
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Asthma is a common disease, and the number of people diagnosed with it increases every year. Although genetic background and environmental exposures play major roles in the development of asthma, one cannot overlook the developmental origin of adult disease or fetal programming theory. This review examines the social, genetic, and environmental factors that are associated with fetal programming of asthma. We also present recent studies from our laboratory that strengthen these observations. It is our hope that the reader will come away with a current view of fetal programming in asthma.
引用
收藏
页码:453 / 459
页数:7
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