Antioxidant and hepatoprotective activities of five eggplant varieties

被引:102
作者
Akanitapichat, Pannarat [1 ]
Phraibung, Kallayanee [1 ]
Nuchklang, Kwunchai [1 ]
Prompitakkul, Suparichart [1 ]
机构
[1] Ubon Ratchathani Univ, Fac Pharmaceut Sci, Ubon Ratchathani 34190, Thailand
关键词
Eggplant; Antioxidant; Hepatoprotective; ANTI PROLIFERATIVE ACTIVITIES; TERT-BUTYL HYDROPEROXIDE; PROTECT HEPG2 CELLS; PHENOLIC-COMPOUNDS; SOLANUM-MELONGENA; OXIDATIVE STRESS; FREE-RADICALS; ASSAY; EXTRACTS; CYTOTOXICITY;
D O I
10.1016/j.fct.2010.07.045
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Eggplant is consumed throughout the world and varies in fruit color, shape, and size. In this study, five varieties of eggplant (purple colored moderate size, white-green colored moderate size, long green, green striped moderate size and pale-green colored small size, respectively, called SM1-SM5) were evaluated for total phenolic and flavonoid content, antioxidant activity and hepatoprotection against cytotoxicity of terr-butyl hydroperoxide (t-BuOOH) in human hepatoma cell lines, HepG2. Total phenolic content found in methanol extracts of SM1-SM5 ranged from 739.36 +/- 1.59 to 1116.13 +/- 7.30 gallic acid equivalents mg/100 g extract and total flavonoid content from 1991.29 +/- 6.32 to 3954.20 +/- 6.06 catechin equivalents mg/100 g extract. SM1 and SM2 which contained high total phenolic and flavonoid had better antioxidant activities than the other varieties. Pretreatment of HepG2 cells with 50 and 100 mu g/mL of SM1-SM5 significantly increased the viability (p < 0.05) of t-BuOOH-exposed HepG2 cells by 14.49 +/- 1.14% to 44.95 +/- 2.72%. The antioxidant activities of the eggplant were correlated with the total amounts of phenolic and flavonoid (r = 0.5310-0.7961). Significant correlation was found between hepatoprotective activities and total phenolic/flavonoid content (r = 0.6371-0.8842) and antioxidant activities (r = 0.5846-0.9588), indicating the contribution of the phenolic antioxidant present in eggplant to its hepatoprotective effect on t-BuOOH-induced toxicity. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码:3017 / 3021
页数:5
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