Time and age dependent decrease of NT-proBNP after septal myectomy in hypertrophic obstructive cardiomyopathy

被引：8

作者：

Cui, Hao ^{[1
,2
]}

Wu, Xi ^{[2
,3
]}

Wang, Shuiyun ^{[1
,2
]}

Tang, Bing ^{[1
,2
]}

Zhu, Changsheng ^{[1
,2
]}

Chen, Haibo ^{[1
,2
]}

Zhou, Xiaohui ^{[1
,2
]}

Wu, Rong ^{[1
,2
]}

Yu, Qinjun ^{[2
,4
]}

Huang, Xiaohong ^{[2
,3
]}

机构：

[1] Chinese Acad Med Sci, Fuwai Hosp, Dept Cardiac Surg, State Key Lab Cardiovasc Dis,Natl Ctr Cardiovasc, 167 Beilishi Rd, Beijing 100037, Peoples R China

[2] Peking Union Med Coll, 167 Beilishi Rd, Beijing 100037, Peoples R China

[3] Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, State Key Lab Cardiovasc Dis, Fuwai Hosp,Dept Cardiol, Beijing, Peoples R China

[4] Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, Fuwai Hosp, Dept Anesthesiol,State Key Lab Cardiovasc Dis, Beijing, Peoples R China

来源：

CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2017年 / 55卷 / 10期

基金：

中国国家自然科学基金;

关键词：

age; hypertrophic cardiomyopathy; myectomy; N-terminal pro-B-type natriuretic peptide (NT-proBNP); remodeling; BRAIN NATRIURETIC PEPTIDE; ECHOCARDIOGRAPHIC ANALYSIS; POPULATION; PREVALENCE;

D O I：

10.1515/cclm-2016-1047

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: NT-proBNP level is a predictive factor in hypertrophic cardiomyopathy patients, in which left ventricular outflow tract obstruction contributes to an increased NT-proBNP level. However, studies regarding the influence of septal myectomy on NT-proBNP level in hypertrophic obstructive cardiomyopathy are lacking. Methods: One hundred and eighty-two patients who underwent septal myectomy in Fuwai Hospital from May 2011 to March 2016 and were included in the present study. Preoperative and follow-up NT-proBNP was retrospectively collected. Correlation analysis was performed to determine the factors affecting preoperative NT-proBNP and postoperative decrease. Results: The cohort had a median age of 46.2 [IQR: 36.5-53.1] years, and 106 (58.2%) patients were male. NT-proBNP decreased to 816.5 [IQR: 400.3-1661.8] pg/mL from preoperative 1732.4 [IQR: 819-3296.5] pg/mL p < 0.001). Baseline NT-proBNP was correlated with gender (p < 0.001), maximum septal thickness (p < 0.001), and resting pressure gradient (p = 0.006). The extent of NT-proBNP decrease was positively correlated with age (p < 0.001), baseline NT-proBNP (p < 0.001), follow-up time (p = 0.020), and enlargement of the ascending aorta (p = 0.019). NT-proBNP exhibited a persistent decrease after myectomy. Conclusions: Myectomy significantly reduced NT-proBNP level in hypertrophic obstructive cardiomyopathy patients, in which a time-dependent manner of decrease indicated myocardial remodeling of the heart after myectomy.

引用

页码：1614 / 1620

页数：7

共 25 条

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