Blindness in dogs with pituitary dependent hyperadrenocorticism: Relationship with glucose, cortisol and triglyceride concentration and with ophthalmic blood flow

被引：9

作者：

Cabrera Blatter, M. F. ^{[1
]}

del Prado, A. ^{[1
]}

Gallelli, M. F. ^{[1
]}

D'Anna, E. ^{[2
]}

Ivanic, J. ^{[1
]}

Esarte, M. ^{[2
]}

Miceli, D. D. ^{[1
]}

Gomez, N. V. ^{[1
]}

Castillo, V. A. ^{[1
]}

机构：

[1] Univ Buenos Aires, Clin Med Pequenos Anim HEMV, Fac Ciencias Vet, RA-1427 Buenos Aires, DF, Argentina

[2] FCV UBA, HEMV, RA-1427 Buenos Aires, DF, Argentina

来源：

RESEARCH IN VETERINARY SCIENCE | 2012年 / 92卷 / 03期

关键词：

Blindness; Hypercortisolism; Glucose; Cortisol; Pituitary dependent hyperadrenocorticism; INSULIN-RESISTANCE; CUSHINGS-SYNDROME; CIRCADIAN-RHYTHM; GLUCOCORTICOIDS; METABOLISM; HORMONE; RISK; ACTH; SIZE; ATHEROSCLEROSIS;

D O I：

10.1016/j.rvsc.2011.04.017

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Pituitary dependent hyperadrenocorticism (PDH) shows a high morbidity and blindness is one of its complications. Compression of the optic chiasm (OC) by the hypophysis adenoma is one of the causes. Another cause could be due to vascular and metabolic alterations of the PDH. Out of a total of 70 dogs with confirmed diagnosis of PDH, 12/70 showed blindness. In only 2/12 the OC was compromised. Electroretinography in dogs without the OC being compromised showed altered A and B wave patterns. Ophthalmological Doppler showed an alteration of the blood flow only in blind dogs without OC compression. Cortisol concentrations (Co), triglycerides (Tg) and glycaemia (G) were greater in 10 dogs with non-compressive blindness vs. dogs with conserved vision. Loss of vision correlated with the increase in these variables. Blindness in dogs with PDH would be related to changes in retinal blood flow, associated to higher Co, Tg and G concentrations. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：387 / 392

页数：6

共 48 条

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