L-DOPS therapy for refractory orthostatic hypotension in autoimmune autonomic neuropathy

被引：24

作者：

Gibbons, CH ^{[1
]}

Vernino, SA ^{[1
]}

Kaufmann, H ^{[1
]}

Freeman, R ^{[1
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Dept Neurol, Autom & Peripheral Nerve Lab, Boston, MA 02215 USA

来源：

NEUROLOGY | 2005年 / 65卷 / 07期

关键词：

D O I：

10.1212/01.wnl.0000178980.83477.14

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors report a 46-year-old woman with antibodies to the nicotinic acetylcholine receptor (NiAchR) of the autonomic ganglia. She presented with severe orthostatic intolerance refractory to treatment with midodrine, fludrocortisone, erythropoietin, vasopressin, salt, and fluid loading. Addition of L-threo-3,4-dihidroxyphenylserine (L-DOPS) substantially improved blood pressure and orthostatic tolerance. L-DOPS may benefit patients with severe orthostatic intolerance and be particularly effective in patients with ganglionic NiAchR antibodies.

引用

页码：1104 / 1106

页数：3

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